지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 607 - 613 (7page)
이용수
초록· 키워드
오류제보하기
The pleura is known as an end target organ of exposure to toxic environmental materials such as fineparticulate matter and asbestos. Moreover, long-term exposure to hazardous materials can eventually leadto fatal lung disease such as diffuse pleural fibrosis or mesothelioma. Chest computed tomography (CT)and ultrasound are gold standard imaging modalities for detection of advanced pleural disease. However,a diagnostic tool for early detection of pleural reaction has not been developed yet due to difficulties inimaging ultra-fine structure of the pleura. Optical coherence tomography (OCT), which provides cross-sectionalimages of micro tissue structures at a resolution of 2-10 μm, can image the mesothelium with a thicknessof ~100 μm and therefore enables investigation of the early pleural reaction. In this study, we inducedthe early pleural reaction according to a time sequence after pleurodesis using talc, which has been widelyused in the clinical field. The pleural reaction in talc grouped according to the time sequence (1st, 2nd,4th weeks) showed a significant thickening (average thickness: 45 ± 7.5 μm, 80 ± 10.7 μm, 90 ± 12.5μm), while the pleural reaction in sham and normal groups showed pleural change from normal to minimalthickening (average thickness: 16 ± 5.5 μm, 17 ± 4.5 μm, 15 ± 6.5 μm, and 12 ± 7.5 μm, 13 ± 2.5μm, 12 ± 3.5 μm). The measurement of pleural reaction by pathologic examinations was well-matchedwith the measurement by OCT images. This is the first study for measuring the thickness of pleuralreactions using a biophotonic modality
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
C. A. Pope III / 2002 / Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution / JAMA 287(9):1132~1141
V. D. Aaron / 2010 / Global estimates of ambient fine particulate matter concentrations from satellitebased aerosol optical depth: development and application / Environ. Health Perspect 118(6):847~855
O. Raaschou-Nielsen / 2016 / Particulate matter air pollution components and risk for lung cancer / Environ. Int 87:66~73
M. Bayram / 2014 / Environmental exposure to asbestos: from geology to mesothelioma / Curr. Opin. Pulm. Med 20(3):301~307
N. Ndlovu / 2013 / Compensation for environmental asbestos-related diseases in South Africa: a neglected issue / Glob. Health Action 6:19410
V. D. Aaron / 2010 / Global estimates of ambient fine particulate matter concentrations from satellitebased aerosol optical depth: development and application / Environ. Health Perspect 118(6):847~855
O. Raaschou-Nielsen / 2016 / Particulate matter air pollution components and risk for lung cancer / Environ. Int 87:66~73
M. Bayram / 2014 / Environmental exposure to asbestos: from geology to mesothelioma / Curr. Opin. Pulm. Med 20(3):301~307
N. Ndlovu / 2013 / Compensation for environmental asbestos-related diseases in South Africa: a neglected issue / Glob. Health Action 6:19410
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