지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 269 - 275 (7page)
이용수
초록· 키워드
오류제보하기
This study has investigated the feasibility of 980-nm low-energy pulsed near-infrared laser stimulationto evoke auditory responses, as well as the effects of radiant exposure and pulse duration on auditoryresponses. In the experiments, a hole was drilled in the basal turn of the cochlea in guinea pigs. An opticalfiber with a 980-nm pulsed infrared laser was inserted into the hole, orientating the spiral ganglion cellsin the cochlea. To model deafness, the tympanic membrane was mechanically damaged. Acousticallyevoked compound action potentials (ACAPs) were recorded before and after deafness, and optically evokedcompound action potentials (OCAPs) were recorded after deafness. Similar spatial selectivity between opticaland acoustical stimulation was found. In addition, OCAP amplitudes increased with radiant exposure,indicating a photothermal mechanism induced by optical stimulation. Furthermore, at a fixed radiantexposure, OCAP amplitudes decreased as pulse duration increased, suggesting that optical stimulation mightbe governed by the time duration over which the energy is delivered. Thus, the current experiments havedemonstrated that a 980-nm pulsed near-infrared laser with low energy can evoke auditory neural responsessimilar to those evoked by acoustical stimulation. This approach could be used to develop optical cochlearimplants.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
World Health Organization / 2006 / Primary Ear and Hearing Care Training Resource, CD-ROM / Stylus Publishing
J. Wells / 2006 / Biophysical mechanisms responsible for pulsed lowlevel laser excitation of neural tissue / Proc. SPIE 6084:60840X
A. D. Izzo / 2006 / Selectivity of optical stimulation in the auditory system / Proc. SPIE 6078:60781P
A. D. Izzo / 2007 / Selectivity of neural stimulation in the auditory system: a comparison of optic and electric stimuli / J. Biomed. Opt 12:021008:1~021008:7
C. P. Richter / 2011 / Neural stimulation with optical radiation / Laser Photon. Rev 5:68~80
J. Wells / 2006 / Biophysical mechanisms responsible for pulsed lowlevel laser excitation of neural tissue / Proc. SPIE 6084:60840X
A. D. Izzo / 2006 / Selectivity of optical stimulation in the auditory system / Proc. SPIE 6078:60781P
A. D. Izzo / 2007 / Selectivity of neural stimulation in the auditory system: a comparison of optic and electric stimuli / J. Biomed. Opt 12:021008:1~021008:7
C. P. Richter / 2011 / Neural stimulation with optical radiation / Laser Photon. Rev 5:68~80
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