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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.3
- 수록면
- 41 - 48 (8page)
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This research was conducted to investigate the antibacterial and anti-inflammatory effects of MeOH Ex. of Salvia miltiorrhiza (MESM) against oral pathogenic bacteria. Minimum inhibitory concentration (MIC), removal effect of biofilm produced by Streptococcus mutans, effect of gene expression of proinflammatory cytokines and effect of production of proinflammatory cytokine of MESM were tested. MESM showed moderated antibacterial activity against oral pathogenic bacteria. About 89±8% of biofilms produced by S. mutans were removed by MESM at a concentration of 1 ㎎/mL. Gene expression of IL-1β and TNF-α induced by Porphyromonas gingivalis were 8~9 folds reduced by MESM. Gene expression of IL-8 induced by Fusobacterium nucelatum were 12 folds reduced by MESM. Production of IL-1β, TNF-α and IL-8 were significantly suppressed by MESM. Conclusively, MESM showed potent antibacterial and anti-inflammatory effect against oral pathogenic bacteria.
목차
Abstract
재료 및 방법
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인용문헌
참고문헌 (33)
참고문헌 신청
Kubiniwa, M. / 2010 / Subgingival biofilm formation / Periodontology 52:38~52
Kah Yan How / 2016 / Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line / Frontiers in Microbiology 7:53
Islam, B. / 2007 / Dental caries : From infection to prevention / Med. Sci. Monit 13:196~203
Han, M. D. / 2000 / Chemical properties of Streptococcus mutans KCTC 3065 polysaccharide purified by fractions / J. Korean Acad. Dent. Health 24:259~270
Kostic, A. D. / 2013 / Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment / Cell Host Microbe 14:207~215
Kah Yan How / 2016 / Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line / Frontiers in Microbiology 7:53
Islam, B. / 2007 / Dental caries : From infection to prevention / Med. Sci. Monit 13:196~203
Han, M. D. / 2000 / Chemical properties of Streptococcus mutans KCTC 3065 polysaccharide purified by fractions / J. Korean Acad. Dent. Health 24:259~270
Kostic, A. D. / 2013 / Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment / Cell Host Microbe 14:207~215
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