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논문 기본 정보

자료유형
학술저널
저자정보
Irfan Kesumayadi (Universitas Diponegoro) Ayyasi Izaz Almas (Universitas Diponegoro) Ilham Nur Hakim Rambe (Universitas Diponegoro) Rebriarina Hapsari (Universitas Diponegoro)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.27 No.1
발행연도
2021.3
수록면
1 - 9 (9page)
DOI
10.20307/nps.2021.27.1.1

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Methicillin-resistant Staphylococcus aureus (MRSA) infection often complicates burn wounds. Mupirocin is the antibiotic of choice for superficial MRSA infection, and its resistance is on the rise due to its frequent and widespread use. This study aimed to develop and evaluate Curcuma xanthorriza extract (CXE)-containing gel as a topical agent against MRSA-infected second-degree burn wound in rats. CXE was obtained using maceration with 96% ethanol. Xanthorrhizol level, antibacterial, and antioxidant activity were evaluated using a standardized method. In vivo, the wound’s healing and bacterial load were evaluated every three days, whereas the histopathology of the wound was examined on day 12 of treatment. One-Way ANOVA and Kruskal-Wallis test were used to analyze the data. In this study, 27.0% and 7.10% of the obtained CXE were xanthorrhizol and curcumin, respectively. Additionally, an IC<SUB>50</SUB> of 64.27 ppm was shown in antioxidant activity measurement, and MIC against MRSA was 5 mg/ml. Treatment with CXE-containing gels showed a significant reduction in bacterial load and proliferation of connective tissue in a dose-dependent manner. In conclusion, CXE-containing gel showed a greater reduction of bacterial load and more advanced wound healing phase than mupirocin.

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Abstract
Introduction
Experimental
Result and Discussion
References

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