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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 57 - 63 (7page)
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Five secoiridoids (1-3, 5, 10), a iridoid (4) three flavonol glycosides (7-9) and a coumarin (6), were isolated from the flowers of Hydrangea paniculata. Their chemical structures were elucidated as kingiside (1), morroniside (2), sweroside (3), loganin (4), vogeloside (5), umbelliferone (6), quercetin-3-O-sambubioside (7), quercetin-3-O-neohesperidoside (8), kaempferol 3-O-sambubioside (9) and secologanin dimethyl acetal (10), respectively, by spectroscopic analysis. All isolated compounds 1-10 were assessed for their ability to induce C2C12 myotube hypertrophy. Among them, loganin (4) and kaempferol 3-O-sambubioside (9) increase the diameter of C2C12 myotubes. All isolated compounds 1-10 were firstly reported from the flowers of Hydrangea paniculata, and the skeletal muscle hypertrophic activity of 4 and 9 was also reported for the first time.
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Abstract
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참고문헌 (22)
참고문헌 신청
Sanchez, A. M., Csibi, A., Raibon, A., Docquier, A., Lagirand-Cantaloube, J., Leibovitch, M.-P., Leibovitch, S. A. and Bernardi, H. (2013) eIF3f: a central regulator of the antagonism atrophy/hypertrophy in skeletal muscle. Int. J. Biochem. Cell Biol. 45: 2158-2162.
Fanzani, A., Conraads, V. M., Penna, F. and Martinet, W. (2012) Molecular and cellular mechanisms of skeletal muscle atrophy: an update. J. Cachexia Sarcopenia Muscle 3: 163-179.
Yin, L., Li, N., Jia, W., Wang, N., Liang, M., Yang, X. and Du, G. (2021) Skeletal muscle atrophy: From mechanisms to treatments. Pharmacol. Res. 172: 105807.
Lee, Y. N. (1996) Flora of Korea, 291, Kyo-Hak Publishing Co., LTD, Seoul.
Zhang, S., Ma, J., Sheng, L., Zhang, D., Chen, X., Yang, J. and Wang, D. (2017) Total coumarins from Hydrangea paniculata show renal protective effects in lipopolysaccharide-induced acute kidney injury via anti-inflammatory and antioxidant activities. Front. Pharmacol. 8: 872.
Fanzani, A., Conraads, V. M., Penna, F. and Martinet, W. (2012) Molecular and cellular mechanisms of skeletal muscle atrophy: an update. J. Cachexia Sarcopenia Muscle 3: 163-179.
Yin, L., Li, N., Jia, W., Wang, N., Liang, M., Yang, X. and Du, G. (2021) Skeletal muscle atrophy: From mechanisms to treatments. Pharmacol. Res. 172: 105807.
Lee, Y. N. (1996) Flora of Korea, 291, Kyo-Hak Publishing Co., LTD, Seoul.
Zhang, S., Ma, J., Sheng, L., Zhang, D., Chen, X., Yang, J. and Wang, D. (2017) Total coumarins from Hydrangea paniculata show renal protective effects in lipopolysaccharide-induced acute kidney injury via anti-inflammatory and antioxidant activities. Front. Pharmacol. 8: 872.
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