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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 198 - 201 (4page)
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초록· 키워드
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Tyrosinase is one of the important enzymes in the mammalian melanin synthesis. In the process of melanin synthesis, tyrosine is oxidized to DOPA (3,4-dihydroxyphenylalanine), and DOPA is further oxidized to dopaquinone. Tyrosinase is an enzyme catalyzing this oxidation of tyrosine, so chemicals that inhibit the activity of tyrosinase can be used as skin whitening agents. In this study, we isolated five constituents from the 80% MeOH extract of Morus bombycis cortex by bioactivity-guided fractionation. We performed mushroom tyrosinase inhibition assay. As a result, 7,2`,4`-trihydroxyflavanone (1), 2`,4`,2,4,-tetrahydroxychalcone (2), and oxyresveratrol (3) showed the more potent inhibitory effect compared to kojic acid, a well-known skin whitening agent with antityrosinase effect. Moracinoside M (4) and moracin M-3`-O-β-D-glucopyranoside (5) also showed the moderate tyrosinase inhibitory activities.
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참고문헌 (13)
참고문헌 신청
박기훈 / 2009 / Tyrosinase Inhibitory Polyphenols from Roots of Morus lhou / JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 57(0):1195~1203
Kanchanapoom, T. / 2002 / Stilbene and 2-Arylbenzofuran Glucosides from the Rhizomes of Schoenocaulon officinale / Chem. Pharm. Bull 50:863~865
Katib, S. / 2005 / Chalcones as potent tyrosinase inhibitors : the importance of a 2, 4-substituted resorcinol moiety / Bioorg. Med. Chem 13:433~441
황재성 / 2002 / Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis / BIOLOGICAL & PHARMACEUTICAL BULLETIN 25:1045~1048
Lim, S.S. / 2001 / Synthesis of flavonoids and their effect on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues / J. Pharm. Pharmacol 53:653~668
Kanchanapoom, T. / 2002 / Stilbene and 2-Arylbenzofuran Glucosides from the Rhizomes of Schoenocaulon officinale / Chem. Pharm. Bull 50:863~865
Katib, S. / 2005 / Chalcones as potent tyrosinase inhibitors : the importance of a 2, 4-substituted resorcinol moiety / Bioorg. Med. Chem 13:433~441
황재성 / 2002 / Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis / BIOLOGICAL & PHARMACEUTICAL BULLETIN 25:1045~1048
Lim, S.S. / 2001 / Synthesis of flavonoids and their effect on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues / J. Pharm. Pharmacol 53:653~668
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