지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 58 - 63 (6page)
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초록· 키워드
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Insampaedok-san is a traditional medicine used for the treatment of colds. We investigated several compounds in Insampeadok-san, and tested their neuroprotective and anti-oxidative activities after fermentation with Lactobacillus. The amounts of four marker compounds (ferulic acid, hesperidin, 6-gingerol and glycyrrhizin) and unidentified compounds in Insampaedok-san (IS) and fermented Insampaedok-san (FIS) were measured and compared by an established HPLC-DAD method. Neuroprotective activity of IS and FIS extracts was evaluated and compared after glutamate-induced neurotoxicity in HT22 cells. Anti-oxidative activity of IS and FIS was also compared in DPPH free radical, hydroxyl radical and hydrogen peroxide scavenging activity assays. Contents of two compounds, ferulic acid and glycyrrhizin were decreased while 6-gingerol was increased by fermentation. FIS showed more potent neuroprotective activity than IS. DPPH, hydroxyl radical and hydrogen peroxide scavenging was slightly increased by FIS when compared to IS. In conclusion, fermentation with Lactobacillus can vary the amounts of the marker compounds in IS and improve neuroprotective and anti-oxidative activities of IS.
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참고문헌 (15)
참고문헌 신청
Braun, S. / 2000 / Dexamethasoneenhanced sensitivity of mouse hippocampal HT22 cells for oxidative stress is associated with the suppression of nuclear factor-kappaB / Neurosci. Lett 295(3):101~104
Chen, X. / 2009 / Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice / Gastroenterol 137(3):914~923
Choi, D.W. / 1998 / Glutamate neurotoxicity and diseases of the nervous system / Neuron 1:623~634
Coyle, J.T / 1993 / Oxidative stress, glutamate, and neurodegenerative disorders / Science 262:689~695
Davis, J.B / 1994 / Protein kinase C activation inhibits glutamateinduced cytotoxicity in a neuronal cell line / Brain Res 652(1):169~173
Chen, X. / 2009 / Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice / Gastroenterol 137(3):914~923
Choi, D.W. / 1998 / Glutamate neurotoxicity and diseases of the nervous system / Neuron 1:623~634
Coyle, J.T / 1993 / Oxidative stress, glutamate, and neurodegenerative disorders / Science 262:689~695
Davis, J.B / 1994 / Protein kinase C activation inhibits glutamateinduced cytotoxicity in a neuronal cell line / Brain Res 652(1):169~173
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