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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 1 - 6 (6page)
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이 논문의 연구 히스토리 (5)
2012
Effect of Pollen from Typha angustata on Hydrogen Peroxide Induced Toxicity in Osteoblastic MC3T3-E1 Cells
Eun Mi Choi
,
Young Soon Lee
동아시아식생활학회 학술발표대회논문집
2012.11
학술대회자료
Effect of Magnolol on the Function of Osteoblastic MC3T3-E1 Cells
Eun Mi Choi
,
Young Soon Lee
동아시아식생활학회 학술발표대회논문집
2012.11
학술대회자료
Protective Effect of Apocynin on Antimycin A-induced Cell Damage in Osteoblastic MC3T3-E1 Cells
Eun Mi Choi
,
Young Soon Lee
동아시아식생활학회 학술발표대회논문집
2012.11
학술대회자료
2008
[P8-108] Stimulation of Osteoblastic Differentiation and Inhibition of Interleukin-6 and Nitric Oxide in MC3T3-E1 Cells by Pomegranate Ethanol Extract
Eun Mi Choi
,
Gun Hee Kim
,
Yong Soo Lee
한국식품영양과학회 학술대회발표집
2008.10
학술대회자료
Chiisanoside, A Lupane Triterpenoid from Acanthopanax Leaves, Stimulates Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
Eun Mi Choi
,
Yan Ding
,
Huu Tung Nguyen
외 6명
Natural Product Sciences
2008.03
학술저널
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The leaves of Acanthopanax species have traditionally been used as a tonic and a sedative as well as in the treatment of rheumatism and diabetes. Chiisanoside is the major active lupane triterpenoid of Acanthopanax leaves. To investigate the bioactivities of chiisanoside, which act on bone metabolism, the effects of chiisanoside on the function of osteoblastic MC3T3-E1 cells were studied. Chiisanoside (0.02-20 μM) significantly increased the growth of MC3T3-E cells and caused a significant elevation of alkaline phosphatase (ALP) activity, collagen content, and nodules mineralization in the cells (P<0.05). The effect of chiisanoside (2 μM) in increasing ALP activity was completely prevented by the presence of tamoxifen, suggesting that the effect of chiisanoside might be partly estrogen receptor mediated. Moreover, cotreatment of p38 inhibitor SB203580 or JNK inhibitor SP600125 inhibited chiisanoside-mediated ALP upregulation, suggesting that the induction of differentiation by chiisanoside is associated with increased activation of p38 and JNK mitogen-activated protein kinases. Our data indicate that the enhancement of osteoblast function by chiisanoside may result in the prevention for osteoporosis.
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