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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 105 - 108 (4page)
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To establish the anti-diabetic(α-glucosidase inhibitory) activity of D. lotus leaf extract, isolate and identify the constituents responsible for the activity. The methanolic extract of leaves was partitioned between water, n-butanol and ethyl acetate. Bio-assay guided fractionation, based on inhibition of α-glucosidase, allowed isolation and identification of the active components. Liquid chromatography/mass spectrometry(LC/MS), <SUP>1</SUP>H-NMR and <SUP>13</SUP>C-NMR spectra analyses demonstrated that the active compound was myricetin-3-O-α-L-rhamnoside(1). Compound 1 demonstrated a strong inhibition on the α-glucosidase, in vitro and α-glucosidase inhibitory value was calculated as 98.08%, when that of a reference drug, acarbose was estimated as 83.03%. The present study indicates compound 1 could be considered as an α-glucosidase inhibitor and developed as an important antidiabetes agent for type II diabetes therapy.
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