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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 72 - 77 (6page)
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One of the most common forms of dementia, Alzheimer`s disease (AD) is a progressive neurodegenerative disorder symptomatically characterized by impairment in memory and cognitive abilities. AD is characterized pathologically by the presence of intracellular neurofibrillary tangles and deposition of β-amyloid (Aβ) peptides, believed to be neurotoxic and now is also considered to have a role on the mechanism of memory dysfunction. In this study, we tested that MeOH extract of Impatiens balsamina L. (IBM) affects on the processing of APP from the APPswe over-expressing Neuro2a cell line. We found that IBM increased over 2 folds of the sAPPα secretion level, a main metabolite of α-secretase. We shown that IBM reduced the secretion level of Aβ42 and Aβ40 without cytotoxicity. BACE (β-site APP cleaving enzyme) FRET assay shown that BACE activity was specifically decreased in the presence of IBM. We suggest that Impatiens balsamina L. may be an useful source to develop a herbal medicine of BACE inhibitor for Alzheimer`s disease.
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참고문헌 (32)
참고문헌 신청
통계청 / 2014 고령자통계
Morris, J. C. / 1996 / Classification of dementia and Alzheimer's disease / Acta Neurol. Scand 165:41~50
Selkoe, D. J. / 1998 / The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease / Trends Cell Biol 8:447~453
Strittmatter, W. J. / 1993 / Binding of human apolipoprotein E to synthetic amyloid beta peptide isoform-specific effects and implications for late-onset Alzheimer disease / Proc. Natl. Acad. Sci. USA 90:8098~8102
Corder, E. H. / 1993 / Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families / Science 261:921~923
Morris, J. C. / 1996 / Classification of dementia and Alzheimer's disease / Acta Neurol. Scand 165:41~50
Selkoe, D. J. / 1998 / The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease / Trends Cell Biol 8:447~453
Strittmatter, W. J. / 1993 / Binding of human apolipoprotein E to synthetic amyloid beta peptide isoform-specific effects and implications for late-onset Alzheimer disease / Proc. Natl. Acad. Sci. USA 90:8098~8102
Corder, E. H. / 1993 / Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families / Science 261:921~923
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