지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 288 - 293 (6page)
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초록· 키워드
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The present study was conducted to evaluate the hair growth-promoting effect of Clitocybin A from mushroom Clitocybe aurantiaca with dermal papilla cells (DPCs), which play important roles in the regulation of hair cycle. Clitocybin A significantly increased the proliferation of immortalized rat vibrissa DPCs. Flow cytometry analysis revealed that Clitocybin A promoted cell-cycle progression through G0/G1 to S phase in immortalized rat vibrissa DPCs. In addition, Clitocybin A increased the level of cell cycle proteins such as cyclin D1, phospho-pRB, and phospho-CDK2. To elucidate the molecular mechanisms of Clitocybin A on the proliferation of DPCs, we examined the activation of wnt/β-catenin signaling which is known to regulate hair follicle development, differentiation and hair growth. Clitocybin A activated wnt/β-catenin signaling via the increase of phospho(ser552)-β-catenin, phospho(ser675)-β-catenin and phospho(ser9)-GSK3β. Furthermore, Clitocybin A markedly increased the activation of extracellular signal-regulated kinase (ERK). These results suggest that the Clitocybin A may induce hair growth by proliferation of DPCs via cell-cycle progression as well as the activation of Wnt/β-catenin signaling and ERK pathway.
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참고문헌 (34)
참고문헌 신청
Price, V. H. / 1999 / Treatment of hair loss / N. Engl. J. Med 341:964~973
Ellis, J. A. / 2002 / Androgenetic alopecia: pathogenesis and potential for therapy / Expert. Rev. Mol. Med 4:1~11
Cotsarelis, G. / 2001 / Towards a molecular understanding of hair loss and its treatment / Trends Mol. Med 7:293~301
Kaufman, K. D. / 1999 / Finasteride, a Type 2 5alpha-reductase inhibitor, in the treatment of men with androgenetic alopecia / Expert. Opin. Investig. Drugs 8:403~415
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
Ellis, J. A. / 2002 / Androgenetic alopecia: pathogenesis and potential for therapy / Expert. Rev. Mol. Med 4:1~11
Cotsarelis, G. / 2001 / Towards a molecular understanding of hair loss and its treatment / Trends Mol. Med 7:293~301
Kaufman, K. D. / 1999 / Finasteride, a Type 2 5alpha-reductase inhibitor, in the treatment of men with androgenetic alopecia / Expert. Opin. Investig. Drugs 8:403~415
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
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