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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 62 - 68 (7page)
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초록· 키워드
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The present study was carried out to investigate the hepatoprotective effect of hot water extract of Korean white dandelion (Taraxacum coreanum Nakai) on liver cancer induced in rats by a single dose of N-nitrosodiethylamine (NDEA). The animals were divided into three groups. The animals in the normal (Nor) group were fed basal diet. Control (Con) group were administered with NDEA (200 mg/kg, i.p.). Hot water extract of Korean white dandelion (KDDA, KDDB) group treated with hot water extracts of Korean white dandelion (30, 60 mg/kg/day) for 8 weeks after NDEA. Serum AST and ALT were measured, enzyme activity of liver were examined by spectrophotometer and histological alternation of liver were examined by light microscopy. KDDA and KDDB group were decreased the increase of serum AST, ALT level induced by NDEA. The activities of SOD and CAT were significantly increased in KDDA, KDDB then in the Con. In the histological observation, KDDA and KDDB group were structure of liver lobula and nuclear shape was relatively cleared. In addition, the cytoplasm staining was similar to those of the Nor group. vacuolization of cytoplasm was not observed. These results suggest that administration of hot water extract of Korean white dandelion suppress or retard liver cancer induced by NDEA in rats.
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참고문헌 (42)
참고문헌 신청
Mendizabal, M. / 2009 / Current management of hepatocellular carcinoma / Med. Clin. North Am 93:885~900
Maluccio, M. / 2012 / Recent progredd in understanding, diagnosing, and treating hepatocellular carcinoma / CA Cancer J. Clin 62:394~399
Korea National Statistical Office / 2013 / Annual report on the cause of death statistics
Fenwick, S. W. / 2003 / The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases Original Research Article / Gastroenterology 125:716~729
Lee, K. W. / 2010 / Review Articles: Liver transplantation for advanced hepatocellular carcinoma / J. Korean Soc. Transplant 24:4~12
Maluccio, M. / 2012 / Recent progredd in understanding, diagnosing, and treating hepatocellular carcinoma / CA Cancer J. Clin 62:394~399
Korea National Statistical Office / 2013 / Annual report on the cause of death statistics
Fenwick, S. W. / 2003 / The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases Original Research Article / Gastroenterology 125:716~729
Lee, K. W. / 2010 / Review Articles: Liver transplantation for advanced hepatocellular carcinoma / J. Korean Soc. Transplant 24:4~12
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