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- 학술저널
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- 2014.3
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Ginsenoside Rg3 (G-Rg3) is one of protopanaxadiol ginsenosides characteristic of red ginseng, steamed and driedginseng (Panax ginseng), which has recently attracted much attention for its antitumor properties in vitro and in vivo animalmodels. Experimental studies have demonstrated that it could promote cancer cell apoptosis, inhibit cancer cell growth, the apoptosisof cancer cells, adhesion, invasion and metastasis, and also prevent an angiogenetic formation in prostate, breast, ovarian,colorectal, gastric, liver and lung cancer etc. It has shown the antitumor activities by modulation of diverse signaling pathways,including regulation of cell proliferation mediators (CDKs and cyclins), growth factors (vascular endothelial growth factor),tumor suppressors (p53 and p21), cell death mediators (caspases, Bcl-2, Bax), inflammatory response molecules (NF-κB andCOX-2), protein kinases (JNK, Akt, and AMP-activated protein kinase) and Wnt/β-catenin signaling. In addition, the combinationof Rg3 and chemotherapeutic agents have synergistically enhanced therapeutic efficacy and reduced antagonisticallyside effects. Furthermore, it can reverse the multidrug resistance of cancer cells, prolong the survival duration and improve lifequality of cancer patients. Taken together, accumulating evidences could provide the potential of G-Rg3 in the treatment of cancers and the feasibility of further randomized placebo controlled clinical trials.
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참고문헌 (90)
참고문헌 신청
Lee, W. H. / 2010 / Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation / Cancer Letters 294:74~81
Wang, C. Z. / 2012 / Herbal medicines as adjuvants for cancer therapeutics / AM. J. Chin. Med 40:657~669
Tan, W. / 2011 / Anti-cancer natural products isolated from chinese medicinal herbs / Chin. Med 6:27
Yun, T. K. / 1983 / Anticarcinogenic effect of long-term oral administration of red ginseng on newborn mice exposed to various chemical carcinogens / Cancer Detect. Prev 6:515~525
Yun, Y. S. / 1987 / Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene / Cancer Detect. Prev 1:301~309
Wang, C. Z. / 2012 / Herbal medicines as adjuvants for cancer therapeutics / AM. J. Chin. Med 40:657~669
Tan, W. / 2011 / Anti-cancer natural products isolated from chinese medicinal herbs / Chin. Med 6:27
Yun, T. K. / 1983 / Anticarcinogenic effect of long-term oral administration of red ginseng on newborn mice exposed to various chemical carcinogens / Cancer Detect. Prev 6:515~525
Yun, Y. S. / 1987 / Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethan and benzo(a)pyrene / Cancer Detect. Prev 1:301~309
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