지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 137 - 146 (10page)
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초록· 키워드
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Dipsaci Radix (Dipsacaceae) has been used as a tonic, an analgesic, anti-inflammatory and anti-complement agents in traditional herbal medicine for the therapy of low back pain, knee pain, rheumatic arthritis, traumatic hematoma, and bone fractures. A high-performance liquid chromatography-electrospray ionization-mass spectrometric method (HPLC-ESI-MS) was developed for the simultaneous quantitation method of the five compounds from the herbal drug: asperosaponin VI and asperosaponin XII (terpene glycosides), sweroside, loganin and dipsacus A(iridoid glycosides). HPLC separation of the analytes was achieved on a C18 column (150 × 2.0 mm i.d., 5 ?m) using the aqueous methanol containing 5 mM ammonium acetate with gradient flow of the mobile phase. Detection of the analytes was performed by positive ion electrospray ionization, and selected ion monitoring was used for data acquisition using m/z corresponding molecular adduct ion, [M+NH<sub>4</sub>] + and [M+H] + . Calibration graphs showed good linearity (r<sup>2</sup> = 0.9997) over the wide range of the analytes; intra- and inter-day precisions (RSD, %) were within 9.1% and the accuracy between 94.0 - 111.0%. Recoveries of the analytes through the assay procedure were in the range of 93.7 - 110.8%. Analytical results of the herbal drugs of Dipsaci Radix (17 samples) show wide distribution of the five marker compounds and clear difference of the species from Phlomidis Radix (4 samples). The developed method would provide a practical guide for the quality control of the herbal drug.
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참고문헌 (29)
참고문헌 신청
Namba, T. / 1980 / The encyclopedia of Waken-Yaku (Tra-ditional Sino-Japanese Medicines) with Color Pictures / Hoiku Publishing Co., LTD. :185~186
Wang, B. X. / 1999 / Contemporary pharmacology of Chinese herbal medicine / Tianjin Science and Technology Press :1263~1264
Zhou, F. W / 1981 / Chinese herbology / Shandong Science and Technology Press :596~597
KFDA / 2007 / The Korean herbal pharmacopoeia / KFDA :222
The state commission of Chinese pharmacopeia / 2005 / Pharmacopoeia of people's republic of China, Part I / Chemical Industry Press :231
Wang, B. X. / 1999 / Contemporary pharmacology of Chinese herbal medicine / Tianjin Science and Technology Press :1263~1264
Zhou, F. W / 1981 / Chinese herbology / Shandong Science and Technology Press :596~597
KFDA / 2007 / The Korean herbal pharmacopoeia / KFDA :222
The state commission of Chinese pharmacopeia / 2005 / Pharmacopoeia of people's republic of China, Part I / Chemical Industry Press :231
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