지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.6
- 수록면
- 1 - 16 (16page)
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We examined the inhibitory activities against monoamine oxidase(MAO) of Gardenia jasminoides in vitro and in vivo methods. Methanolic extract and ethylacetate fraction of Gardenia jasminoides fruit showed a significant inhibitory activity on MAO-A and MAO-B in vitro. The IC50 values of each fraction on MAO-A and MAO-B are as followed; total methanol extracts 1.23 and 1.34mg/㎖, EtOAc fraction 0.72 and 0.77 mg/㎖. Water-soluble fraction also showed IC50 values of 0.81 mg/㎖ on MAO-B. MAO-A activity was increased by the oral administration of ethanolic extract of G. jasminoides, while MAO-B activity was decreased. The concentration of serotonin of brain tissue administrated of ethanolic extract of G. jasminoides is slightly increased in rat. This tendency is not different from the activity of deprenyl which is a well known MAO inhibitor was used as a positive control. Consequently, we suggest that G. jasminoides may have the effects on the inhibitory activity against MAO. This activity of G. jasminoides is considerable for development of functional materials for treatment and control of depression, dementia, Parkinson` disease, stress and promoting exercise, etc.
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UCI(KEPA) : I410-ECN-0101-2023-518-000074054