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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.3
- 수록면
- 109 - 117 (9page)
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Arachidonic acid (AA), which is stored in membrane glyceropholipids, is liberated by phospholipase A_2 (PLA_2) enzymes and is sequentially converted to cyclooxygenase(COX) and lipoxygenase (LOX) then to various bioactive prostaglandins (PGs,) and leukotrienes (LTs). In order to find the specific inhibitors of AA metabolism enzymes such as PLA_2, COX-2, 5-LO and lyso PAF acetyltransferase, 195 Korean indigenous plant extracts were evaluated for their inhibitory activity on PGD_2, LTC_4 production from cytokine-induced mouse bone marrow-derived mast cells (BMMC) and arachidonic acid released from phospholipid and PAF production from lyso PAF. From this screening procedure, methanol extract of eight plants such as Saururus chinensis, Aster tataricus, Chrysanthemum cinerariaefolium, Reynoutria japonica, Discorea nipponica, Epimedium Koreanum, Impatiens textori, Veronica rotunda var. subintegra were found to inhibit production of inflammatory mediators in vitro assay system.
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