지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 642 - 653 (12page)
이용수
초록· 키워드
오류제보하기
Background: Effective strategies are dramatically needed to prevent and improve the recovery from myocardial ischemia and reperfusion (I/R) injury. Direct interactions between the mitochondria and endoplasmic reticulum (ER) during heart diseases have been recently investigated. This study was designed to explore the cardioprotective effects of gypenoside XVII (GP-17) against I/R injury. The roles of ER stress, mitochondrial injury, and their crosstalk within I/R injury and in GP-17einduced cardioprotection are also explored. Methods: Cardiac contractility function was recorded in Langendorff-perfused rat hearts. The effects of GP-17 on mitochondrial function including mitochondrial permeability transition pore opening, reactive oxygen species production, and respiratory function were determined using fluorescence detection kits on mitochondria isolated from the rat hearts. H9c2 cardiomyocytes were used to explore the effects of GP-17 on hypoxia/reoxygenation.
Results: We found that GP-17 inhibits myocardial apoptosis, reduces cardiac dysfunction, and improves contractile recovery in rat hearts. Our results also demonstrate that apoptosis induced by I/R is predominantly mediated by ER stress and associated with mitochondrial injury. Moreover, the cardioprotective effects of GP-17 are controlled by the PI3K/AKT and P38 signaling pathways.
Conclusion: GP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress through the PI3K/AKT and P38 signaling pathways.
Results: We found that GP-17 inhibits myocardial apoptosis, reduces cardiac dysfunction, and improves contractile recovery in rat hearts. Our results also demonstrate that apoptosis induced by I/R is predominantly mediated by ER stress and associated with mitochondrial injury. Moreover, the cardioprotective effects of GP-17 are controlled by the PI3K/AKT and P38 signaling pathways.
Conclusion: GP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress through the PI3K/AKT and P38 signaling pathways.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart
The Korean Journal of Physiology & Pharmacology
2024 .05
-
Efficacy study of Angelica gigas in a rat myocardial ischemia/reperfusion injury model
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Mitochondrial dysfunction in kidney injury, inflammation, and disease: potential therapeutic approaches
Kidney Research and Clinical Practice
2020 .01
-
Ischemia reperfusion injury of liver and development of an experimental platform
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Strain and Strain Rate Echocardiography in Rat Myocardial Ischemia Reperfusion Injury Model
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Role of the mitochondrial stress response in human cancer progression
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Mitochondrial fatty acid metabolism in acute kidney injury
의생명과학
2018 .01
-
Evaluation of bioenergetic and mitochondrial function in liver transplantation
Clinical and Molecular Hepatology
2019 .01
-
Mitochondrial targeted strategies and their application for cancer and other diseases treatment
Journal of Pharmaceutical Investigation
2020 .01
-
Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review
Journal of Yeungnam Medical Science
2023 .04
-
Pharmacological Approaches to Limit Ischemic and Reperfusion Injuries of the Heart: Analysis of Experimental and Clinical Data on P2Y12 Receptor Antagonists
Korean Circulation Journal
2022 .10
-
Metformin alleviates left ventricular diastolic dysfunction in a rat myocardial ischemia reperfusion injury model
한국실험동물학회 학술발표대회 논문집
2020 .07
-
The effects of mitochondrial toxicity during myocardial differentiation in 3D model
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Ginsenoside compound K protects against cerebral ischemia/reperfusion injury via Mul1/Mfn2-mediated mitochondrial dynamics and bioenergy
Journal of Ginseng Research
2023 .05
-
Ginsenoside Rg1 reduces cardiac inflammation against myocardial ischemia/reperfusion injury by inhibiting macrophage polarization
Journal of Ginseng Research
2024 .11
-
Effects of gas signaling molecule SO2 in cardiac functions of hyperthyroid rats
The Korean Journal of Physiology & Pharmacology
2024 .03
-
Phosphorylation in Novel Mitochondrial Creatine Kinase Tyrosine Residues Render Cardioprotection against Hypoxia/Reoxygenation Injury
지질·동맥경화학회지
2021 .01
-
Rescue of Heart Failure by Mitochondrial Recovery
International Neurourology Journal
2016 .01
-
Ischemia-reperfusions injury model in cynomolgus monkeys
한국실험동물학회 학술발표대회 논문집
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2022-524-001132966