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초록· 키워드
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Herein, we present a simple, precise, accurate, and ultra-sensitive spectrofluorimetric method for estimation of clozapine (CLZ) in tablets and human plasma was developed and then validated. A highly fluorescent brown-yellowish fluorophore was formed (λ<SUB>ex</SUB>=469 ㎚, λ<SUB>emi</SUB>=540 ㎚) as a nucleophilic substitution reaction occurred between CLZ and 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) in alkaline mcllavine buffer (pH 9.0). Optimum values of experimental parameters were carefully determined and optimized. The calibration curve was rectilinear over the concentration range of 80-900 ng mL<SUP>−1</SUP> with a linear correlation coefficient (r=0.9984). The LOD and LOQ were determined to be 14 ng mL<SUP>−1</SUP> and 42 ng mL<SUP>−1</SUP>, respectively. The proposed approach has been used successfully to quantification of Clozapine in its commercial formulations and human plasma.
목차
Abstract
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References
참고문헌 (36)
참고문헌 신청
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M. G. Choc, F. Hsuan, G. Honigfeld, W. T. Robinson, L. Ereshefsky, M. L. Crismon, S. R. Saklad, J. Hirschowitz and R. Wagner, Pharm. Res., 7(4), 347-351 (1990).
M. A. Raggi, V. Pucci, F. Bugamelli and V. Volterra, J. AOAC Int., 84(2), 361-367 (2001).
A. Essali, N. A. H. Haasan, C. Li and J. Rathbone, Cochrane Database Syst. Rev., 2009(1), 1-174 (2009).
D. Siskind, L. McCartney, R. Goldschlager and S. Kisely, Br. J. Psychiatry, 209(5), 385-392 (2016).
M. G. Choc, F. Hsuan, G. Honigfeld, W. T. Robinson, L. Ereshefsky, M. L. Crismon, S. R. Saklad, J. Hirschowitz and R. Wagner, Pharm. Res., 7(4), 347-351 (1990).
M. A. Raggi, V. Pucci, F. Bugamelli and V. Volterra, J. AOAC Int., 84(2), 361-367 (2001).
A. Essali, N. A. H. Haasan, C. Li and J. Rathbone, Cochrane Database Syst. Rev., 2009(1), 1-174 (2009).
D. Siskind, L. McCartney, R. Goldschlager and S. Kisely, Br. J. Psychiatry, 209(5), 385-392 (2016).
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