지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 94 - 108 (15page)
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초록· 키워드
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Tumor peptides associated with MHC class I molecules or their synthetic variants have attracted great attention for their potential use as vaccines to induce tumor-specific CTLs. However, the outcome of clinical trials of peptide-based tumor vaccines has been disappointing. There are various reasons for this lack of success, such as difficulties in delivering the peptides specifically to professional Ag-presenting cells, short peptide half-life in vivo, and limited peptide immunogenicity. We report here a novel peptide vaccination strategy that efficiently induces peptide-specific CTLs. Nanoparticles (NPs) were fabricated from a biodegradable polymer, poly(D,L-lactic-co-glycolic acid), attached to H-2K<SUP>b</SUP> molecules, and then the natural peptide epitopes associated with the H-2K<SUP>b</SUP> molecules were exchanged with a model tumor peptide, SIINFEKL (OVA<SUB>257-268</SUB>). These NPs were efficiently phagocytosed by immature dendritic cells (DCs), inducing DC maturation and activation. In addition, the DCs that phagocytosed SIINFEKL-pulsed NPs potently activated SIINFEKL-H-2K<SUP>b</SUP> complex-specific CD8<SUP>+</SUP> T cells via cross-presentation of SIINFEKL. In vivo studies showed that intravenous administration of SIINFEKL-pulsed NPs effectively generated SIINFEKL-specific CD8<SUP>+</SUP> T cells in both normal and tumor-bearing mice. Furthermore, intravenous administration of SIINFEKL-pulsed NPs into EG7.OVA tumor-bearing mice almost completely inhibited the tumor growth. These results demonstrate that vaccination with polymeric NPs coated with tumor peptide-MHC-I complexes is a novel strategy for efficient induction of tumor-specific CTLs.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (39)
참고문헌 신청
Durgeau A / 2018 / Recent advances in targeting CD8 T-cell immunity for more effective cancer immunotherapy / Front Immunol 9:14
Malonis RJ / 2020 / Peptide-based vaccines : current progress and future challenges / Chem Rev 120:3210~3229
Wagner S / 2018 / Colorectal cancer vaccines : Tumor-associated antigens vs neoantigens / World J Gastroenterol 24:5418~5432
Tanna JG / 2019 / Critical testing and parameters for consideration when manufacturing and evaluating tumor-associated antigen-specific T cells / Cytotherapy 21:278~288
Schietinger A / 2008 / Specificity in cancer immunotherapy / Semin Immunol 20:276~285
Malonis RJ / 2020 / Peptide-based vaccines : current progress and future challenges / Chem Rev 120:3210~3229
Wagner S / 2018 / Colorectal cancer vaccines : Tumor-associated antigens vs neoantigens / World J Gastroenterol 24:5418~5432
Tanna JG / 2019 / Critical testing and parameters for consideration when manufacturing and evaluating tumor-associated antigen-specific T cells / Cytotherapy 21:278~288
Schietinger A / 2008 / Specificity in cancer immunotherapy / Semin Immunol 20:276~285
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UCI(KEPA) : I410-ECN-0101-2022-517-000121166