지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 220 - 231 (12page)
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초록· 키워드
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Background: The aging of lip skin is influenced by genetic and environmental factors. The presence of lip wrinkles is known to increase with aging. Many treatment modalities for lip wrinkle reduction have been developed in the field of dermatology and the development of simple and easy treatment modality with less side effects is required. Asiaticoside, a component isolated from Centella asiatica, also has shown improyed wound healing effects, even in the infected wounds. It has been reported that wound and ulcer healing are enhanced via promoting fibroblast proliferation and collagen synthesis. The purpose of this study was to evaluate the effect of asiaticoside on the improvement of lip and perioral wrinkle in vitro and in vivo. Material and Methods • Cultured fibroblast and 54 human volunteers were used for in vitro and in vivo studies respectively, Asiaticoside was administered to the fibroblast culture system and was also applied to the fine and coarse lip wrinkles of the human volunteers twice daily for 8 weeks. Numeric and morphologic changes and procollagen type I c-peptide(PICP) content were measured in fibroblastes with MTT assay method and PICP EIA assay respectively. Also the effect of asiaticoside on lip and peroral fine and coarse wrinkle lesions was examined by using an image analysis system with skin replica and subjective and objective assessment of wrinkle were evaluated. Results: 1) In vitro study (1) The number of cultured fibroblast was compared to the control group. (2) Procollagen type I c-peptide of cultured compared to the control group(p<0.05). 2) In vivo study (1) The change of wrinkle area was measured by using an image analysis system with skin replica. The study showed significant decrease at the wrinkle area in the 0.2% asiaticoside applied group(p<0.01). Significant differences were identified between the 0.2% asiaticoside applied group and the control group in the study(p<0.01). The wrinkle area at 4 and 8 weeks after the application showed significant decrease in the 0.2% asiaticoside applied group than in the control group(p<0.05). (2) In the subjective visual assessment by the investigator the 0.2% asiaticoside applied group showed improvement of the wrinkles on the lip (p<0.01). Significant differences were identified between the 0.2% asiaticoside applied group and the control group in the study(p<0.01). At 8 weeks after the application, the 0.2% asiaticoside applied group showed significant improvement of wrinkles on the lip(P<0.05). (3) In the subjective visual assessment by the subjects themselves at 4 and 8 weeks after the application, the 0.2% asiaticoside applied group showed more self satisfaction than the control group. Conclusion ‘ In vitro asiaticoside induced collagen synthesis. In vivo the improvement of the wrinkles was identified in the asiaticoside applied group. It is suggested that asiaticoside may treat or reduce wrinkle on the lip. not increased in the 5，10 and 20 ᄍ g/ml asiaticoside treated group fibroblast was increased in the 10, 20 fxg/ml asiaticoside treated group
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