지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 388 - 391 (4page)
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A biodegradable and porous poly(L-lactide-co-glycolide) (PLGA) scaffold has been proposed for the application of cytokine carrier and tissue engineered spinal cord. The brain-derived neurotrophic factor (BDNF) loaded PLGA scaffolds was prepared by ice-particle leaching method to control release from porous polymer scaffolds. The release amount of BDNF from BDNF loaded PLGA scaffold was observed about 4 weeks period in vitro at phosphate buffered saline (PBS, pH 7.4) at 37oC and analyzed by enzyme-linked immunosorbent assay (ELISA). Prepared PLGA scaffold had uniform porosity and good interconnection between pores. Release amount of BDNF increased with increasing BDNF content. These results suggest that the released BDNF from BDNF loaded PLGA scaffold such as conduit type can be very useful for the nerve regeneration in the neural tissue engineering area.
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