지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 383 - 387 (5page)
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초록· 키워드
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Adipose derived stromal cells (ADSCs) are very similar to MSCs and can differentiate into mesenchymal lineage and nonmesenchymal lineage. ADSCs are very easily obtained than MSCs and no pain to acquire cells. Recently researches revealed that MSCs have nonspecific immune suppressive effect on lymphocyte proliferation. We studied about whether nonself ADSCs have lymphocyte suppressive effect on mixed lymphocyte culture (MLR) like MSCs. First we obtained 1st passaged ADSCs and tested whether these cells have stem cell characteristics. We confirmed induced cell by ALP and Oil red O staining. For immune suppressive effect test, ADSC were co-cultured with reaction lymphocyte and stimulator lymphocyte. We defined nonself ADSCs could suppression lymphocyte proliferation in MLR and two more cell number treatment could suppression lymphocyte proliferation 5-fold. Accordingly we found out ADSCs can lymphocyte suppression by dose-dependent pattern. In nonspecific immune suppression test by PHA as non specific lymphocyte stimulator, ADSCs can suppression PHA induced lymphocyte proliferation. In conclusion, it is our belief that ADSCs cells can alternative sources of MSCs in clinically usage and also remain carefully treatment.
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