지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 130 - 137 (8page)
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초록· 키워드
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Bone marrow stromal cells (BMSCs) were harvested from the femurs and tibias of adult female Fischer rat. BMSCs were suspended at 2×106 cell/mL in poly(L-lactide-co-glycolide) (PLGA) which was saturated with 0.5 ml methylene chloride. The ability of the PLGA with BMSCs to be integrated and to promote nerve regeneration in the transected rat spinal cord was investigated. Fischer rat received an implant consisting of the BMSCs suspended in the PLGA in a 5 mm gap (at position; T8~T9) created by the spinal cord resection. For histological evaluation, the implanted regions were removed after 4 and 8 weeks. Thin sections were cut from paraffin embedded tissue and histological sections were stained hematoxylin and eosin staining. Motor functional outcome measurements using the Basso-Beattie-Bresnehan (BBB) score performed weekly during 8 weeks of post-injury. It was observed that the effects of the PLGA with BMSCs on neuroinduction (Group III, with scaffold, cell & cytokine) are stronger that PLGA without BMSCs (Group II, with scaffold only) and blank model (Group I). In conclusion, these results suggest that BMSCs and BDNF may have an important role for spinal cord regeneration of tissue engineering.
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