지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 164 - 169 (6page)
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-The purpose of our study was to determine the concentrations of cytokine profiles in the chronic ACL-deficient knee and reconstructed knee. Nineteen patients, who were undertaken ACL reconstruction using patellar tendon autograft, were enrolled. Group A(n=4) was normal contralateral knee. Group B(n=10) was pure ACL-deficient knee. Group C(n=9) was ACL-deficient and cartilage injured knee. Group D(n=10) was pure ACL-reconstructed knee. Group E(n=9) was ACL-reconstructed and debridement & partial meniscectomized knee. Joint fluid from group B and C was obtained at post-trauma 3 months, group D and E at post-operation one year. IL-1β, TNF-α, IL-6 and MMP-3 was analyzed using ELISA. TNF-α, IL-1β, MMP-3, IL-6 was higher concentration in ACL-deficient knee than normal knee. ACL-deficient and cartilage damaged knee had higher concentration of all 4 cytokines than pure ACL-deficient knee. IL-1β, TNF-α, IL-6 concentration in ACL-reconstructed knee was higher than normal, but decreased than ACL-deficient knee. MMP-3 concentration was decreased to nearly normal after ACL reconstruction. After ACL reconstruction the cytokine profile was approaching to normal, but not returned to normal after surgery one year. We need more cases and follow-up period to evaluate relationship between ACL-reconstructed knee and osteoarthritis.
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