지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.47 No.5
- 발행연도
- 2004.1
- 수록면
- 692 - 697 (6page)
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초록· 키워드
오류제보하기
Background: The pringle maneuver (PM), hepatic inflow occlusion, during hepatic surgery reduces intraoperative bleeding and blood transfusion requirement, but hepatic ischemia/reperfusion injury is inevitable. During ischemia, xanthine oxidoreductase is converted to xanthine oxidase (XO), which can serve as a critical source of reactive oxygen species (reduces O2 to O2․-) that contribute to inflammatory signaling, ischemia-reperfusion injury, and an impaired vascular function. The purpose of the present study was to follow changes of XO activity and O2․- production during hepatic surgery under PM. Methods: Eleven patients that underwent hepatectomy under intermittent PM were studied. Blood was withdrawn before PM, and 10 and 20 minutes after final reperfusion. Plasma XO activity was measured using a spectrophotometer after incubating plasma with/without xanthine for one-hour. Superoxide (O2․-) production was followed by measuring by cytochrome c reduction by plasma XO. Results: After final reperfusion, plasma XO activity had increased four-fold (0.36 ± 0.06 to 1.25 ± 0.25 mU/ml) with a concomitant increase in O2․- production (0.66 ± 0.29 to 1.66 ± 0.40μM/min). Conclusions: Significantly more XO is released into the systemic circulation after intermittent PM, with subsequently increased O2․- production. The significant contribution of XO to hepatic surgery under PM might be beneficially managed using an anesthetic with a known antioxidative effect. (Korean J Anesthesiol 2004; 47: 692～7)
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