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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 117 - 123 (7page)
- DOI
- 10.15188/kjopp.2021.08.35.4.117
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초록· 키워드
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Gefitinib, a first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI), provides obvious clinical benefit in patients with EGFR-mutant non-small cell lung cancer (NSCLC). However, patients ultimately develop gefitinib resistance which mainly caused by EGFR T790M secondary mutation. In the current study, we investigated whether the root extract of Scutellaria baicalensis (SB) overcomes gefitinib resistance. Gefitinib-resistant H1975 human NSCLC cells (EGFR L858R/ T790M double mutant) were treated with gefitinib and/or ethanol extract of SB (ESB) to evaluate the effect of ESB on the gefitinib sensitivity. The cell viability was measured by MTT assay and trypan blue exclusion assay. The colony-forming ability was evaluated by anchorage-dependent colony formation assay. Combined treatment with gefitinib and ESB markedly decreased the cell viability and colony formation than single treatment with gefitinib or ESB in H1975 cells. In addition, cells treated with both gefitinib and ESB exhibited a significant increase of sub-G1 DNA content which indicates apoptotic cells compared with those treated with gefitinib or ESB alone. As a molecular mechanism, combined treatment with gefitinib and ESB strongly downregulated the phosphorylation of ERK and JNK than single treatment with gefitinib or ESB. Taken together, our results demonstrate that ESB sensitizes H1975 cells to gefitinib treatment. We cautiously propose that ESB can be used in combination with gefitinib for the advanced NSCLC patients with acquired resistance to EGFR TKIs.
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재료 및 방법
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Reference
참고문헌 (27)
참고문헌 신청
Siegel RL / 2021 / Cancer Statistics, 2021 / CA Cancer J Clin 71(1):7~33
Kris MG / 2014 / Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs / JAMA 311(19):1998~2006
Zhang YL / 2016 / The prevalence of EGFR mutation in patients with non-small cell lung cancer : a systematic review and meta-analysis / Oncotarget 7(48):78985~78993
Scaltriti M / 2006 / The epidermal growth factor receptor pathway : a model for targeted therapy / Clin Cancer Res 12(18):5268~5272
Mok TS / 2009 / Gefitinib or carboplatin–paclitaxel in pulmonary adenocarcinoma / N Engl J Med 361(10):947~957
Kris MG / 2014 / Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs / JAMA 311(19):1998~2006
Zhang YL / 2016 / The prevalence of EGFR mutation in patients with non-small cell lung cancer : a systematic review and meta-analysis / Oncotarget 7(48):78985~78993
Scaltriti M / 2006 / The epidermal growth factor receptor pathway : a model for targeted therapy / Clin Cancer Res 12(18):5268~5272
Mok TS / 2009 / Gefitinib or carboplatin–paclitaxel in pulmonary adenocarcinoma / N Engl J Med 361(10):947~957
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