지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 300 - 306 (7page)
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초록· 키워드
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Treatment of the injured peripheral nerve with a long defect remains one of the most difficult problems in nerve reconstructive surgery. Adipose derived mesenchymal stem cells(MSCs) have the potential to differentiate into neuronal and adipose tissue and osteogenic cells. We investigated the effect of MSCs on histological and functional regeneration of facial nerve. After transection of facial nerve in twenty rats, we divided the experimental animals into four groups. In five rats, direct anastomosis was done. In fifteen rats, nerve defect were connected with silicone tubes which were left empty or filled with fibrin or filled with fibrin and MSCs. MSCs were tagged with ferumoxides before transplantation. After 8 weeks, motion of the vibrissae was analyzed and histological examinations were performed. Amplitude and frequency of vibrissae were significantly larger in MSCs group. On H&E and anti-S100 immunohistochemical staining, the maximal diameter of the regenerated nerves was significantly larger in MSCs group. On Prussian blue staining, we could identify the MSCs in the regenerated nerve. We concluded that transplantation of MSCs into a facial nerve gap substantially increased axonal regeneration.
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