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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 78 - 85 (8page)
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Nickel can be exposed to human population from air, food, and water sources by which may produce abnormal consequences in organs including kidneys, liver, cardiovascular, immune, and reproductive systems. Recognition of nickel biomarkers for the toxicity assessment is of prime importance. Caenor-habditis elegans (C. elegans) is well known animal model for genetic studies which serves as a living biosensor in ecotoxicological researches. Our study is the first evidence demonstrating changes of genomic expression in C. elegans in response to nickel (II) acetate using nematode-specific microarray. We have found 23 genes as a nickel responsive genes that were differentially expressed (¤2 fold) following 24 hours exposure to nickel acetate. The analysis of gene onto-logy revealed molecular components involved in detoxification, carcinogenesis, and oxidative stress defense in the C. elegans exposed to the nickel. In addition, using the comparative toxicogenomics database, we have deduced the nickel-affected molecular mechanisms including histone modification and its stability. In conclusion, our investigation would be able to present precise route for understanding impor- tant roles of several nickel responsive genes in nickel toxicity. Furthermore, our discovery also provides significant biomarkers in response to nickel acetate. This might be virtue for monitoring and evaluating hazard risk in the field of ecotoxicology.
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참고문헌 (36)
참고문헌 신청
Kasprzak, K.S / 2003 / Nickel carcinogenesis / Mutat. Res 533:67~97
Kodipura, D / 2004 / Nickel-induced oxidative stress in testis of mice: evidence of DNA damage and genotoxic effects / J. Androl 25:996~1003
Wozniak, K / 2004 / Nickel impairs the repair of UV- and MNNG-damaged DNA / Cell Mol. Biol. Lett 9:83~94
Harkin, A / 2003 / A toxicokinetic study of nickel-induced immunosuppression in rats. Immunopharmacol / Immunotoxicol 25:655~670
Pandey, R / 1999 / Male reproductive effect of nickel sulphate in mice / Biometals 12:339~346
Kodipura, D / 2004 / Nickel-induced oxidative stress in testis of mice: evidence of DNA damage and genotoxic effects / J. Androl 25:996~1003
Wozniak, K / 2004 / Nickel impairs the repair of UV- and MNNG-damaged DNA / Cell Mol. Biol. Lett 9:83~94
Harkin, A / 2003 / A toxicokinetic study of nickel-induced immunosuppression in rats. Immunopharmacol / Immunotoxicol 25:655~670
Pandey, R / 1999 / Male reproductive effect of nickel sulphate in mice / Biometals 12:339~346
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