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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 19 - 26 (8page)
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이 논문의 연구 히스토리 (5)
2006
Identification of VOCs-Induced Immune Responsive Genes in Human Promyelocytic Leukemia (HL-60) Cells
Sailend
,
a Nath Sa
,
ma
외 3명
환경독성보건학회 심포지엄 및 학술대회
2006.11
학술대회자료
Toxicogenomics Study on Benzene, Toluene and o-Xylene induced immune responsive genes in Human promyelocytic leukemia (HL-60) Cells
Sailend
,
a Nath Sa
,
ma
외 2명
환경독성보건학회 심포지엄 및 학술대회
2006.11
학술대회자료
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초록· 키워드
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Ethylbenzene (EBZ) and trichloroethy-lene (TCE), the volatile organic compounds (VOCs) are common constituents of cleaning and degreasing agents, paints, pesticides, personal care products, gasoline and solvents. They are the most common waste chemicals from industry. EBZ is classified as a possible carcinogen and TCE is also classified as a probable carcinogen. This study analyzed the genome-wide expression profiles of human promyelocytic leukemia HL-60 cells exposed to EBZ and TCE using a 35-K whole human genome oligonucleotide microarray. Exposure to EBZ and TCE altered the expression of 106 and 332 up- and also 171 and 856 down-regulated genes individually, 44 genes were up-regulated, and 81 common genes were down-regulated. Genes with a significantly increased expression levels (over 1.5 fold and p-values ⁄0.05) with EBZ and TCE were then classified with gene ontology (GO) and KEGG pathway annotation. Clustering of differentially expressed common genes were associated with RIG-I-like receptor signaling pathway, cytokine-cytokine receptor interaction, toll-like signaling pathway, and small cell lung cancer. GO analysis showed that the major categories in the biological process ontology were immune response, regulation of apoptosis, regu-lation of programmed cell death, regulation of cell death, and defense response ontology. Functionally important immune response and apoptosis related genes were also validating their expression profiles by quantitative real-time RT-PCR. Thus, this study may provides a valuable information to do further analysis to explore the mechanism of EBZ and TCE induced hematotoxicity.
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참고문헌 (27)
참고문헌 신청
Nikodinovic, J / 2008 / The conversion of BTEX compounds by single and defined mixed cultures to medium- chain-length polyhydroxyalkanoate / Appl. Microbiol. Biotechnol 80:665~673
IARC / 1995 / Dry cleaning, some chlorinated solvents and other industrial chemicals / IARC Monogr. Eval. Carcinog. Risks Hum 63:74~185
Plaza, G.A / 2007 / Utilization of monocyclic aromatic hydrocarbons individually and in mixture by bacteria isolated from petroleum-contaminated soil / World J. Microbiol. Biotechnol 23:533~542
Liu, Y.T / 1988 / Increased subjective symptom prevalence among workers exposed to trichloroethylene at sub-OEL levels / Tohoku J. Exp. Med 155:183~195
McCunney, R.J / 1988 / Diverse manifestations of trichloroethylene / Br. J. Ind. Med 45:122~126
IARC / 1995 / Dry cleaning, some chlorinated solvents and other industrial chemicals / IARC Monogr. Eval. Carcinog. Risks Hum 63:74~185
Plaza, G.A / 2007 / Utilization of monocyclic aromatic hydrocarbons individually and in mixture by bacteria isolated from petroleum-contaminated soil / World J. Microbiol. Biotechnol 23:533~542
Liu, Y.T / 1988 / Increased subjective symptom prevalence among workers exposed to trichloroethylene at sub-OEL levels / Tohoku J. Exp. Med 155:183~195
McCunney, R.J / 1988 / Diverse manifestations of trichloroethylene / Br. J. Ind. Med 45:122~126
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