지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Codonopsis lanceolata L. (Campanulaceae) has long been used in traditional Korean medicine to treat bronchitis,cough, and inflammatory diseases, however, the efficacy of anti-tumor activities remains to be defined. In this study the effects of Codonopsis lanceolata (C. lanceolata) on proliferation, migration and adhesion in lung (A549, H1299)and ovarian cancer (SKOV-3) cells were investigated. To assess and compare the pharmacological effects and production places of C. lanceolata, the ethanolic extracts of C. lanceolata from different places in Korea (Hongseong,Yecheon, Yeongwol, Yanggu, Gangjin, and Hoengseong) were prepared. The extract from Hoengseong county did have only marginal anti-proliferative activity in all the cell lines tested, however, other extracts had little or no effect on cell proliferation. The extracts from Hongseong, Gangjin or Hoengseong county had partial anti-migratory activity in lung cancer cells, but not in ovarian cancer cells. In addition, the extract from Hoengseong county had partial anti-adhesive activity in ovarian cancer cells, however, other extracts did not affect cell adhesion in both lung and ovarian cancer cells. Taken together, these findings provide the first description of anti-tumor efficacy of C. lanceolata from different production places in Korea, and suggest that C. lanceolata from Hoengseong county may have therapeutic potential in lung and ovarian cancers.
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참고문헌 (15)
참고문헌 신청
Alper O / 2001 / Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells / J. Natl. Cancer Inst 93:1375~1384
변세은 / 200905 / Regulatory effects of Codonopsis lanceolata on gene expression of GM-CSF in macrophage-like cells / JOURNAL OF ETHNOPHARMACOLOGY 123(1):185~189
Chang YK / 1986 / Chemical studies on the alkaloidal constituents of Codonopsis lanceolata / Yakhak Hoeji 30:1~7
Keunsook Cho / 2009 / Protective Effect of Codonopsis lanceolata Root Extract Against Alcoholic Fatty Liver in the Rat / Journal of Medicinal Food 12(6):1293~1301
Goldberg DM / 1995 / Does wine work / Clin. Chem 41:14~16
변세은 / 200905 / Regulatory effects of Codonopsis lanceolata on gene expression of GM-CSF in macrophage-like cells / JOURNAL OF ETHNOPHARMACOLOGY 123(1):185~189
Chang YK / 1986 / Chemical studies on the alkaloidal constituents of Codonopsis lanceolata / Yakhak Hoeji 30:1~7
Keunsook Cho / 2009 / Protective Effect of Codonopsis lanceolata Root Extract Against Alcoholic Fatty Liver in the Rat / Journal of Medicinal Food 12(6):1293~1301
Goldberg DM / 1995 / Does wine work / Clin. Chem 41:14~16
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