지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 701 - 707 (7page)
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초록· 키워드
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We designed a randomized, double blinded, 3-months controlled prospective clinical
study to investigate effects of oral uridine on the ocular surface in dry eye patients.
Twenty-seven patients who diagnosed as dry eye with lower than 5 mm of
wetting in the Schirmer strip, with corneal epithelial erosion and who completely
followed-up till 3 months were enrolled. Corneal-conjunctival fluorescein staining,
non-anesthetic Schirmer test, impression cytology, and Ocular Surface Disease
Index (OSDI) were evaluated in the experimental and placebo groups at the baseline,
1 and 3 months after start of medication in a double blinded manner. Fluorescein
stain score of the cornea was markedly decreased in oral uridine group compared
to the placebo group at 3 months after medication (P=0.032, Mann-Whitney
U test). The Schirmer wetting score for the oral uridine group was significantly increased
(P=0.001, Wilcoxon signed rank test) at 3 months and its difference between
two groups was statistically significant (P=0.030, Mann-Whitney U test). OSDI scores
were significantly decreased at 1 and 3 months in treatment group. Oral uridine is
effective in treatment of dry eyes.
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