지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 668 - 673 (6page)
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초록· 키워드
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This study was undertaken to evaluate the incidence and risk factors associated
with relative adrenal insufficiency (RAI) in Korean critically-ill patients. All patients
who were admitted to the Medical Intensive Care Unit (MICU) of Samsung Medical
Center between January 1, 2006 and April 30, 2007 were prospectively evaluated
using a short corticotropin stimulation test on the day of admission. RAI was
defined as an increase in the serum cortisol level of <9 ㎍/dL from the baseline after
administration of 250 ㎍ of corticotropin. In all, 123 patients were recruited and overall
the incidence of RAI was 44% (54/123). The presence of septic shock (P=0.001),
the Simplified Acute Physiology Score (SAPS) II (P=0.003), the Sequential Organ
Failure Assessment (SOFA) score (P=0.001), the mean heart rate (P=0.040), lactate
levels (P=0.001), arterial pH (P=0.047), treatment with vasopressors at ICU
admission (P=0.004), and the 28-day mortality (P=0.041) were significantly different
between patients with and without RAI. The multivariate analysis showed that
the SOFA score was an independent predictor of RAI in critically-ill patients (odd
ratio=1.235, P=0.032). Our data suggest that RAI is frequently found in Korean critically-
ill patients and that a high SOFA score is an independent predictor of RAI in
these patients.
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