지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 520 - 524 (5page)
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초록· 키워드
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Clostridium difficile (C. difficile) is a common causative agent of pseudomembranous
colitis (PMC). C. difficile-associated diarrhea (CDAD) ranges from mild diarrhea to
life threatening PMC. Recently, a highly virulent strain of C. difficile polymerase chain
reaction ribotype 027 was found in North America, Europe, and Japan. A 52-yr-old
woman with anti-tuberculosis medication and neurogenic bladder due to traffic accident
experienced five episodes of C. difficile PMC after taking antibiotics for pneumonia
along with septic shock and acute renal failure. She was readmitted to the
intensive care unit and treated with oral vancomycin with refractory of oral metronidazole,
inotropics and probiotics for over 60 days. C. difficile isolated both at the
first and the last admission was identified as C. difficile ribotype 027 by ribotyping,
toxinotyping, and tcdC gene sequencing, which turned out the same pathogen as
the epidemic hypervirulent B1/NAP1 strain. This is the first case of C. difficile PCR
ribotype 027 in Korea. After discharge, she was maintained on probiotics and rifaximin
for 3 weeks. She had no relapse for 6 months.
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