지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 218 - 222 (5page)
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초록· 키워드
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Risk-reducing surgery is known as the most powerful preventive strategy for BRCA mutation carriers. This current case report represents the first documentation of the contralateral prophylactic mastectomy (CPM) and bilateral salphingooophorectomy (BSO) in a carrier of BRCA mutation in Korea. The patient was a 39-year-old woman who was seen in at a genetic counseling clinic for discussing of risk-reducing strategies for the breast and ovarian cancer. She presented at the age of 38 year with a 1.5 cm sized, grade 3, and ER/PR/HER2 negative infiltrating ductal carcinoma of the right breast. She was treated with wide local excision of the right breast and sentinel lymph node biopsy of the axilla. She was then treated with CAF (Cyclophosphamide+Doxorubicin+5-Fluorouracil) chemotherapy and radiation therapy. She was initially counseled at the time of surgery due to the family history of her mother, who suffered with breast cancer at the age of 58. After the completion of chemotherapy, we received the genetic test results and it was positive for the BRCA1 mutation (3746_3747insA). After a long discussion of cancer surveillance and risk-reducing options, she decided to undergo ipsilateral mastectomy and CPM and BSO. Before surgery, psychiatric consultation was done and questionnaires evaluating her depression, anxiety, body image, quality of life, and psychological distress were filled out. After discussion with the plastic surgeon, she decided to undergo delayed reconstruction of the breast. We performed endoscopic bilateral skin-sparing mastectomy and a laparoscopic bilateral salphingo-oophorectomy. There was no complication after surgery and the pathologic examination revealed no evidence of cancer in both breasts and ovaries. We think that CPM and BSO are feasible risk-reducing options for the breast cancer patients with the BRCA mutation in Korea.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Claus EB / 1996 / The genetic attributable risk of breast and ovarian cancer / Cancer 77:2318~2324
Friedman LS / 1994 / Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families / Nat Genet 8:399~404
Wooster R / 1995 / Identification of the breast cancer susceptibility gene BRCA2 / Nature 378:789~792
Son BH / 2008 / Korean Breast Cancer Society. Hereditary breast cancer in Korea: a review of the literature / J Breast Cancer 11:1~9
Hartmann LC / 1999 / Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer / N Engl J Med 340:77~84
Friedman LS / 1994 / Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families / Nat Genet 8:399~404
Wooster R / 1995 / Identification of the breast cancer susceptibility gene BRCA2 / Nature 378:789~792
Son BH / 2008 / Korean Breast Cancer Society. Hereditary breast cancer in Korea: a review of the literature / J Breast Cancer 11:1~9
Hartmann LC / 1999 / Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer / N Engl J Med 340:77~84
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