지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 185 - 196 (12page)
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Heart transplantation is the last treatment option in refractory end stage heart failure, which can prolong survival. The number of heart transplantations has increased and the survival rate has improved during the last few decades which was contributed by advanced understanding of immunologic mechanism of rejection, pharmaceutical development and clinical management of donors and recipients. However, only a fraction of patients can be offered to transplantation due to shortage of donor heart and many patients suffer high mortality while waiting. Meanwhile, technical advancement of mechanical assist device in recent years enabled long term implantable left ventricular assist devices (LVAD) to bridge the patients with high mortality in the waiting list to transplantation and to assist as a long term destination therapy for patients who are not eligible for transplantation. Development of solid phase assay increased the sensitivity and the specificity of detection of anti-human leukocyte antigen (HLA) antibodies in the recipient. It enabled identifying unacceptable HLA antigens, acquire calculated Panel Reactive Antibodies and perform virtual cross match that can enhance the efficacy of donor allocation system to decrease the waiting time, obviate prospective cross match to decrease ischemic time and to assess the risk of rejection in presensitized patients. Antibody mediated rejection is a challenging entity in diagnosis and management. However, standardized classification of histology and immunology of endomyocardial biopsies was made recently and immunotherapy is moving toward targeted therapies directed at antibody production and function. This review focuses on those major changes in the heart transplantation field in the last decade.
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참고문헌 (51)
참고문헌 신청
Lund LH / 2013 / The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report--2013; focus theme: age / J Heart Lung Transplant 32:951~964
Kinkhabwala MP / 2013 / Patient selection for cardiac transplant in 2012 / Expert Rev CardiovascTher 11:179~191
Colvin-Adams M / 2012 / Lung and heart allocation in the United States / Am J Transplant 12:3213~3234
The Korean Liver Cancer Study Group;National Cancer Center / Practice guidelines for management of hepatocellular carcinoma
The Organ Procurement and Transplantation Network / Annual Data Report
Kinkhabwala MP / 2013 / Patient selection for cardiac transplant in 2012 / Expert Rev CardiovascTher 11:179~191
Colvin-Adams M / 2012 / Lung and heart allocation in the United States / Am J Transplant 12:3213~3234
The Korean Liver Cancer Study Group;National Cancer Center / Practice guidelines for management of hepatocellular carcinoma
The Organ Procurement and Transplantation Network / Annual Data Report
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