지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Puberty is a complex and coordinated biologic process of sexual development that leads to complete gonadal maturation and function, and attainment of reproductive capacity. The pubertal activation of pulsatile gonadotropinreleasing hormone (GnRH) secretion requires coordinated changes in excitatory and inhibitory neurotransmitters, growth factors, and a group of transcriptional regulators. Kisspeptin and its putative receptor, G protein-54 signaling complex, have recently emerged as essential gatekeepers of GnRH activation. Precocious puberty is defined as the onset of secondary sexual characteristics before the age of 8 years for girls and 9 years for boys. The prevalence of precocious puberty is rapidly increasing in Korea. Factors affecting early puberty include genetic traits, nutrition, and exposure to endocrine disrupting chemicals. Precocious puberty may cause psychosocial problems with inappropriate early biological maturation and significant impairment of final height due to accelerated bone maturation. In rapidly progressing central precocious puberty, GnRH agonists appear to increase final height without significant side effects, if administered in the early stages. Further large-scale randomized controlled studies of the long-term safety and efficacy of GnRH agonist treatment are needed.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Grumbach MM / 2011 / Williams textbook of endocrinology / Saunders :1054~1108
Semple RK / 2005 / Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism / J Clin Endocrinol Metab 90:1849~1855
Seminara SB / 2003 / The GPR54 gene as a regulator of puberty / N Engl J Med 349:1614~1627
Shahab M / 2005 / Increased hypothalamic GPR54 signaling : a potential mechanism for initiation of puberty in primates / Proc Natl Acad Sci U S A 102:2129~2134
Tena-Sempere M / 2013 / Keeping puberty on time : novel signals and mechanisms involved / Curr Top Dev Biol 105:299~329
Semple RK / 2005 / Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism / J Clin Endocrinol Metab 90:1849~1855
Seminara SB / 2003 / The GPR54 gene as a regulator of puberty / N Engl J Med 349:1614~1627
Shahab M / 2005 / Increased hypothalamic GPR54 signaling : a potential mechanism for initiation of puberty in primates / Proc Natl Acad Sci U S A 102:2129~2134
Tena-Sempere M / 2013 / Keeping puberty on time : novel signals and mechanisms involved / Curr Top Dev Biol 105:299~329
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