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자료유형
학술저널
저자정보
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.12 No.4
발행연도
2014.1
수록면
299 - 305 (7page)

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Background/Aims: Antibiotic usage and increasingly aging populations have led to increased incidence of Clostridium difficile infection (CDI) in worldwide. Recent studies in Korea have also reported increasing CDI incidence; however, there have been no reports on the long-term outcomes of CDI. We therefore investigated the long-term clinical outcomes of patients with CDI, including delayed recurrence, associated risk factors and mortality. Methods: Hospitalized patients diagnosed with CDI at Seoul Paik Hospital between January 2007 and December 2008 were included. Their medical records were retrospectively investigated. ‘Delayed recurrence’ was defined as a relapse 8 weeks after a successful initial treatment. Multivariate logistic regression analysis was performed to identify risk factors for the delayed recurrence. Kaplan-Meier curves were used to analyze mortality rates. Results: A total of 120 patients were enrolled; among them, 87 were followed-up for at least 1 year, with a mean follow-up period of 34.1±25.1 months. Delayed recurrence was observed in 17 patients (19.5%), and significant risk factors were age (over 70 years, P=0.049), nasogastric tube insertion (P=0.008), and proton pump inhibitor or H2-blocker treatments (P=0.028). The 12- and 24-month mortality rates were 24.6% and 32.5%, respectively. No deaths were directly attributed to CDI. Conclusions: Delayed recurrence of CDI was not rare, occurring in 19.5% of the study population. Although CDI-related mortality was not reported, 2-year (32.5%) mortality rate of CDI patients implies that a CDI diagnosis may predict severe morbidity and poor prognosis of the underlying disease.
#Clostridium difficile #Recurrence #Mortality #Risk factors

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참고문헌 (38)

참고문헌 신청
Ricciardi R / 2007 / Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States / Arch Surg 142:624~631 google schola Cohen SH / 2010 / Clinical practice guidelines for Clostridium difficile infection in adults : 2010 update by the society for healthcare epidemiology of America(SHEA)and the infectious diseases society of America(IDSA) / Infect Control Hosp Epidemiol 31:431~455 google schola Lee JK / 2005 / Comparative value of sigmoidoscopy and stool cytotoxin-A assay for diagnosis of pseudomembranous colitis / Intest Res 3:61~67 google schola Pepin J / 2005 / Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada / Clin Infect Dis 40:1591~1597 google schola Jawa RS / 2012 / Clostridium difficile-associated infection : a disease of varying severity / Am J Surg 204:836~842 google schola

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