지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 5 - 11 (7page)
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초록· 키워드
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Human cytomegalovirus (HCMV) is a member of the herpesvirus family. HCMV infection persists throughout the host lifespan in a latent state following primary infection. The ability of HCMV to escape control by the host immune system and its resulting reactivation suggests the importance of ongoing immune surveillance in the prevention of HCMV reactivation. HCMV is a common cause of opportunistic infection that causes severe and fatal disease in immune-compromised individuals. In inflammatory bowel disease patients, particularly those with ulcerative colitis (UC), HCMV is often reactivated because these patients are frequently treated with immunosuppressive agents. This reactivation exacerbates colitis. Additionally, HCMV infection can induce severe colitis, even in patients with UC who have never been treated with immunosuppressive agents. However, the role of HCMV in colonic inflammation in patients with UC remains unclear. Here, we present previous and current clinical data on the diagnosis and treatment of HCMV infection in UC. Additionally, our experimental data from a newly established mouse model mimicking UC with concomitant CMV infection clearly demonstrate that inflammation could result in the exacerbation of UC disease activity with induction of HCMV reactivation. In summary, optimal control of colonic inflammation should be achieved in UC patients who are refractory to conventional immunosuppressive therapies and are positive for HCMV.
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참고문헌 (58)
참고문헌 신청
Nakase H / 2008 / Systematic review : cytomegalovirus infection in inflammatory bowel disease / J Gastroenterol 43:735~740
Loftus EV, Jr / 1994 / Cytomegalovirus as an exacerbating factor in ulcerative colitis / J Clin Gastroenterol 19:306~309
Cooper HS / 1977 / Cytomegalovirus inclusions in patients with ulcerative colitis and toxic dilation requiring colonic resection / Gastroenterology 72:1253~1256
Osaki R / 2008 / Acute cytomegalovirus infection superimposed on corticosteroid-naive ulcerative colitis / Intern Med 47:1341~1344
Matsuoka K / 2007 / Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients / Am J Gastroenterol 102:331~337
Loftus EV, Jr / 1994 / Cytomegalovirus as an exacerbating factor in ulcerative colitis / J Clin Gastroenterol 19:306~309
Cooper HS / 1977 / Cytomegalovirus inclusions in patients with ulcerative colitis and toxic dilation requiring colonic resection / Gastroenterology 72:1253~1256
Osaki R / 2008 / Acute cytomegalovirus infection superimposed on corticosteroid-naive ulcerative colitis / Intern Med 47:1341~1344
Matsuoka K / 2007 / Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients / Am J Gastroenterol 102:331~337
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