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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Endocrine disruptors are known to cause harmful effects to humanthrough various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer. Using diverse biological tools, the potential molecular mechanisms related with these diseases by exposure of endocrine disruptors. Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals. In this review, we initially summarize the major molecular mechanisms involved in the induction of the above mentioned diseases by endocrine disruptors. Additionally, we provide the potential markers and signaling mechanisms discovered via pathway analysis under exposure to representative endocrine disruptors, bisphenol, diethylhexylphthalate, and nonylphenol. The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.
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참고문헌 (100)
참고문헌 신청
National Institute of Environmental Health Science / Endocrine disruptors fact sheet
Schecter A / 2004 / Polybrominated diphenyl ethers contamination of United States food / Environ Sci Technol 38:5306~5311
Cichna-Markl M / 2012 / Sample clean-up by sol-gel immunoaffinity chromatography for the determination of bisphenol A in food and urine / Methods 56:186~191
Charles JW / 2009 / Changes in indoor pollutants since the 1950s / Atmos Environ 43:153~169
Sharpe RM / 2004 / How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? / BMJ 328:447~451
Schecter A / 2004 / Polybrominated diphenyl ethers contamination of United States food / Environ Sci Technol 38:5306~5311
Cichna-Markl M / 2012 / Sample clean-up by sol-gel immunoaffinity chromatography for the determination of bisphenol A in food and urine / Methods 56:186~191
Charles JW / 2009 / Changes in indoor pollutants since the 1950s / Atmos Environ 43:153~169
Sharpe RM / 2004 / How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? / BMJ 328:447~451
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