지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Seamustard and seatangle are commonly consumed seaweeds in Korea and rich sources of non-digestible polysaccharides which possess biological activities. However anti-mutagenic and anti-cancer activities of these seaweeds under physiological condition have not been clarified yet. The objective of this study was to investigate the effect of seaweeds consumption on azoxymethane (AOM)-induced DNA methylation at N7 and O6 position of guanine base, an indicator of DNA damage related to cancer initiation.
Methods: Thirty ICR mice were divided into five groups and fed one of the following diets for two weeks: control diet, diet containing 10% water-soluble or water-insoluble fraction of seamustard or seatangle. After two weeks of experimental diet AOM was injected at 6 hours before sacrifice and N7-methylguanine (N7-meG) and O6-methylguanine (O6-meG) from the colon and liver DNA were quantified using a gas chromatography-mass spectroscopy.
Results: Water-soluble fractions of both seamustard and seatangle significantly reduced AOM-induced production of N7-meG guanine in colon and liver. Also water-soluble fractions of these seaweeds suppressed the level of methylation at O6-guanine of colon and liver directly responsible for tumorigenesis. While water-insoluble fraction of seamustard suppressed the production of N7-meG in liver this seaweed fraction decreased O6-meG and the ratio of O6/N7-meG in liver. Water insoluble fraction of seatangle decreased both O6- and N7-meG in colon and liver. Supplementation of all seaweeds extracts increased fecal weight of animals and the increase of fecal weight by water-insoluble fraction of seaweeds were higher than that by water-soluble fraction.
Conclusion: Seamustard and seatangle intake may effectively prevent colon and liver carcinogenesis by decreasing DNA damage and the mechanism of inhibiting carcinogenesis by seaweeds in a long term study are warranted.
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참고문헌 (44)
참고문헌 신청
Hebert JR / 1996 / Nutritional, socioeconomic, and reproductive factors in relation to female breast cancer mortality: findings from a cross-national study / Cancer Detect Prev 20:234~244
Teas J / 2013 / The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle / J Appl Phycol 25:771~779
Alekseyenko TV / 2007 / Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga / Bull Exp Biol Med 143:730~732
Ermakova S / 2011 / Fucoidans from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata: structural characteristics and anticancer activity / Appl Biochem Biotechnol 164:841~850
Kim EJ / 2010 / Fucoidan present in brown algae induces apoptosis of human colon cancer cells / BMC Gastroenterol 10:96
Teas J / 2013 / The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle / J Appl Phycol 25:771~779
Alekseyenko TV / 2007 / Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga / Bull Exp Biol Med 143:730~732
Ermakova S / 2011 / Fucoidans from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata: structural characteristics and anticancer activity / Appl Biochem Biotechnol 164:841~850
Kim EJ / 2010 / Fucoidan present in brown algae induces apoptosis of human colon cancer cells / BMC Gastroenterol 10:96
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