지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 46 - 53 (8page)
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초록· 키워드
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Objective: The purpose of this study was to develop a risk prediction score for distinguishing benign ovarian mass from malignant tumors using CA-125, human epididymis protein 4 (HE4), ultrasound findings, and menopausal status. The risk prediction score was compared to the risk of malignancy index and risk of ovarian malignancy algorithm (ROMA).
Methods: This was a prospective, multicenter (n=6) study with patients from six Asian countries. Patients had a pelvic mass upon imaging and were scheduled to undergo surgery. Serum CA-125 and HE4 were measured on preoperative samples, and ultrasound findings were recorded. Regression analysis was performed and a risk prediction model was developed based on the significant factors. A bootstrap technique was applied to assess the validity of the HE4 model.
Results: A total of 414 women with a pelvic mass were enrolled in the study, of which 328 had documented ultrasound findings. The risk prediction model that contained HE4, menopausal status, and ultrasound findings exhibited the best performance compared to models with CA-125 alone, or a combination of CA-125 and HE4. This model classified 77.2% of women with ovarian cancer as medium or high risk, and 86% of women with benign disease as very-low, low, or medium-low risk. This model exhibited better sensitivity than ROMA, but ROMA exhibited better specificity. Both models performed better than CA-125 alone.
Conclusion: Combining ultrasound with HE4 can improve the sensitivity for detecting ovarian cancer compared to other algorithms.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Jemal A / 2009 / Cancer statistics / CA Cancer J Clin 59:225~249
du Bois A / 2009 / Variations in institutional infrastructure, physician specialization and experience, and outcome in ovarian cancer: a systematic review / Gynecol Oncol 112:422~436
Bristow RE / 2013 / Adherence to treatment guidelines for ovarian cancer as a measure of quality care / Obstet Gynecol 121:1226~1234
Jacobs I / 1990 / Grudzinskas JG. A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer / Br J Obstet Gynaecol 97:922~929
Moore RG / 2009 / A novel multiple marker bioassay utilizing HE4 and CA125for the prediction of ovarian cancer in patients with a pelvic mass / Gynecol Oncol 112:40~46
du Bois A / 2009 / Variations in institutional infrastructure, physician specialization and experience, and outcome in ovarian cancer: a systematic review / Gynecol Oncol 112:422~436
Bristow RE / 2013 / Adherence to treatment guidelines for ovarian cancer as a measure of quality care / Obstet Gynecol 121:1226~1234
Jacobs I / 1990 / Grudzinskas JG. A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer / Br J Obstet Gynaecol 97:922~929
Moore RG / 2009 / A novel multiple marker bioassay utilizing HE4 and CA125for the prediction of ovarian cancer in patients with a pelvic mass / Gynecol Oncol 112:40~46
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