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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.21 No.2
- 발행연도
- 2015.1
- 수록면
- 217 - 221 (5page)
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초록· 키워드
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Background/Aims It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle. Methods Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and response to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled water was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10-6, 10-5, 10-4, and 10-3 M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured. Results The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth intervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Naseri E / 2006 / Proton pump inhibitors, omeprazole and lansoprazole induce relaxation of isolated human arteries / Eur J Pharmacol 531:226~231
Aydın C / 2003 / Relaxant effect of omeprazole and lansoprazole in guinea pig gallbladder muscle strips in vitro / J Gastroenterol 38:765~771
Bagcıvan I / 2002 / Hydrogen-potassium ATPase inhibitors induce relaxation on rabbit prostatic strips in vitro / Int J Urol 9:641~644
Sarıoglu Y / 2000 / Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro / Life Sci 66:1411~1421
Yıldırım K / 2001 / Inhibitor effect of omeprazole in isolated human myometrial smooth muscle / Life Sci 69:435~442
Aydın C / 2003 / Relaxant effect of omeprazole and lansoprazole in guinea pig gallbladder muscle strips in vitro / J Gastroenterol 38:765~771
Bagcıvan I / 2002 / Hydrogen-potassium ATPase inhibitors induce relaxation on rabbit prostatic strips in vitro / Int J Urol 9:641~644
Sarıoglu Y / 2000 / Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro / Life Sci 66:1411~1421
Yıldırım K / 2001 / Inhibitor effect of omeprazole in isolated human myometrial smooth muscle / Life Sci 69:435~442
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