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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 916 - 922 (7page)
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Study Design: The study was conducted on patients who received autologous conditioned serum (ACS) as a line of treatment at the Orthopedics outpatient department of Post Graduate Institute of Medical Education and Research (PGIMER, Chandigarh) from January 2011 to June 2012. Of the 1,224 patients, 20 males or females were included in the study based on the inclusion and exclusion criteria. The institutional board of PGIMER approved the study before it was initiated. Purpose: To study the efficacy of ACS in the treatment of unilateral lumbar radiculopathy. Overview of Literature: Interleukin (IL)-1 appears to be of special importance among the cytokines identified in orthopedic diseases. ACS contains high concentrations of IL-1 receptor antagonist, antagonist to IL-1 in that is a biochemical ‘sensitizer’ of nerve roots in radiculopathy. Methods: We included 20 patients with unilateral lumbar radiculopathy after obtaining informed consent. We prepared ACS as described by Meijer et al. Under bi-planar fluoroscopic imaging in anterior-posterior and lateral views, ACS was administered via epidural perineural technique. Patients in both groups were evaluated by quadruple visual analogue scale, straight leg raising test, revised Oswestry disability index, and 12-Item Short Form of Health Survey before and after epidural injections at 3 weeks, 3 months, and 6 months. Results: There was a statistically significant change in all parameters from pre-injection to first, second, and third follow-up (p <0.001). Conclusions: ACS can modify the disease course in addition to reducing pain, disability and improving general health.
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참고문헌 (16)
참고문헌 신청
Mooney V / 1996 / Evaluation and treatment of low back pain / Clin Symp 48:1~32
Anderson DG / 2005 / Molecular pathogenic factors in symptomatic disc degeneration / Spine J 5(6 Suppl):260S~266S
Spangfort EV / 1972 / The lumbar disc herniation: a computer- aided analysis of 2,504 operations / Acta Orthop Scand Suppl 142:1~95
Saal JA / 1996 / Natural history and nonoperative treatment of lumbar disc herniation / Spine (Phila Pa 1976) 21(24 Suppl):2S~2S
Saal JS / 1995 / The role of inflammation in lumbar pain / Spine (Phila Pa 1976) 20:1821~1827
Anderson DG / 2005 / Molecular pathogenic factors in symptomatic disc degeneration / Spine J 5(6 Suppl):260S~266S
Spangfort EV / 1972 / The lumbar disc herniation: a computer- aided analysis of 2,504 operations / Acta Orthop Scand Suppl 142:1~95
Saal JA / 1996 / Natural history and nonoperative treatment of lumbar disc herniation / Spine (Phila Pa 1976) 21(24 Suppl):2S~2S
Saal JS / 1995 / The role of inflammation in lumbar pain / Spine (Phila Pa 1976) 20:1821~1827
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