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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective：We aimed to explore the influence of depression on working memory in patients with mild cognitive impairment (MCI) and dementia. Methods：Clinical and neuropsychological data of 43 subjects with mild cognitive impairment (MCI) (n=17) and dementia (n= 26) who had visited Department of Psychiatry at Soonchunhyang University Seoul Hospital, were collected. The subjects were divided into depressed (n=18) and non-depressed (n=25) groups based on the Korean version of Short Geriatric Depression Scale. Two-way analysis of variance test was conducted to evaluate the influence of diagnosis (MCI and dementia), the presence of depression and their interaction on working memory which was measured by digit forward and backward span test. Results：Among the patients with MCI, test score of digit backward span test in depressed group was significantly lower than in non-depressed group. However, among the patients with dementia, there was no significant difference in digit backward span test between depressed and non-depressed groups. Conclusion：This study suggests that the depression could deteriorate working memory measured by digit backward span test in patients with MCI, relative to in patients with dementia and it also implicates the diagnostic assessment for depression has clinically importance in patients with MCI.
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참고문헌 (56)
참고문헌 신청
Wang S / 2015 / Depression and cognition in the elderly / Annu Rev Clin Psychol 11:331~360
Cummings JL / 1995 / Depressive symptoms in Alzheimer disease : assessment and determinants / Alzheimer Dis Assoc Disord 9:87~93
Ellison JM / 2008 / Beyond the"C"in MCI : noncognitive symptoms in amnestic and non-amnestic mild cognitive impairment / CNS Spectr 13:66~72
Byers AL / 2011 / Depression and risk of developing dementia / Nat Rev Neurol 7:323~331
Steenland K / 2012 / Late-life depression as a risk factor for mild cognitive impairment or Alzheimer’s disease in 30 US Alzheimer's disease centers / J Alzheimers Dis 31:265~275
Cummings JL / 1995 / Depressive symptoms in Alzheimer disease : assessment and determinants / Alzheimer Dis Assoc Disord 9:87~93
Ellison JM / 2008 / Beyond the"C"in MCI : noncognitive symptoms in amnestic and non-amnestic mild cognitive impairment / CNS Spectr 13:66~72
Byers AL / 2011 / Depression and risk of developing dementia / Nat Rev Neurol 7:323~331
Steenland K / 2012 / Late-life depression as a risk factor for mild cognitive impairment or Alzheimer’s disease in 30 US Alzheimer's disease centers / J Alzheimers Dis 31:265~275
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