지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Curcumin is a natural polyphenolic compound with a variety of beneficial activities. However, its application as a functional ingredient is currently limited because of its poor aqueous solubility and bioavailability. In this study, oilin-water nanoemulsions containing curcumin were prepared by microfluidization to improve solubility and bioavailability of curcumin. The effects of emulsifier type and concentrations, the homogenizing pressure (40-140 MPa) and number of cycles on particle size parameters and stability of nanoemulsions were investigated. The results showed that particle size of the nanoemulsion was considerably decreased from 126 nm to 55 nm with increasing homogenization pressure, number of cycles and emulsifier concentration. The optimum conditions for nanoemulsion preparation were determined to be homogenization pressure of 120 MPa and 3 cycles. The storage study showed that the curcumin nanoemulsions were physically stable for about 8 weeks at room temperature.
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참고문헌 (19)
참고문헌 신청
Ahmed K / 2012 / Nanoemulsionand emulsion-based delivery systems for curcumin: Encapsulation and release properties / Food Chem 132:799~807
Basnet P / 2011 / Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment / Molecules 16:4567~4598
Chan MMY / 1998 / In Vivo Inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties / Biochem. Pharmacol 55:1955~1962
Chang CL / 1997 / Controlled formation of silica particles from tetraethyl orthosilicate in nonionic water-in-oil microemulsions / Langmuir 13:3295~3307
Duvoix A / 2005 / Chemopreventive and therapeutic effects of curcumin / Cancer Lett 223:181~190
Basnet P / 2011 / Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment / Molecules 16:4567~4598
Chan MMY / 1998 / In Vivo Inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties / Biochem. Pharmacol 55:1955~1962
Chang CL / 1997 / Controlled formation of silica particles from tetraethyl orthosilicate in nonionic water-in-oil microemulsions / Langmuir 13:3295~3307
Duvoix A / 2005 / Chemopreventive and therapeutic effects of curcumin / Cancer Lett 223:181~190
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