지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 752 - 760 (9page)
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초록· 키워드
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Background and Objectives: Cardiac involvement is frequent in systemic amyloidosis and is the most important determinant of the clinical outcome. The aims of this study were to assess the incidence and prognosis of cardiac amyloidosis and discuss the diagnostic issues related to cardiac amyloidosis.
Subjects and Methods: We retrospectively studied all patients diagnosed with systemic amyloidosis who presented to our institution from January 1999 to December 2011.
Results: Of the 129 patients with systemic amyloidosis, cardiac amyloidosis was diagnosed in 62 patients. At the 3 years’ follow-up of the patients with systemic amyloidosis, there was a statistically significant difference in mortality between patients with cardiac amyloidosis and the rest of the patients (58.1% vs. 37.3%, p=0.008). In the Cox proportional hazard model, old age {hazard ratio (HR) 18.336, p=0.006}, elevation of cardiac troponin I (cTNI) (HR 13.246, p=0.020), left ventricular (LV) systolic dysfunction (HR 5.137, p=0.041) and diastolic dysfunction (HR 64.595, p=0.022) were independently associated with survival in cardiac amyloidosis. In the diagnosis of monoclonal gammopathy, serum or urine protein electrophoresis was not sensitive enough to be used clinically compared to serum free light chain assay (35.8% vs. 96.4%).
Conclusion: In systemic amyloidosis, cardiac involvement was the most important determinant of the prognosis, and old age, elevation of cTNI, LV systolic dysfunction and diastolic dysfunction were independently associated with survival in cardiac amyloidosis.
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참고문헌 (30)
참고문헌 신청
Merlini G / 2004 / The systemic amyloidoses: clearer understandingof the molecular mechanisms offers hope for more effectivetherapies / J Intern Med 255:159~178
Westermark P / 2002 / Amyloid fibril proteinnomenclature -- 2002 / Amyloid 9:197~200
Duston MA / 1987 / Diagnosis of amyloidosisby abdominal fat aspiration. Analysis of four years’ experience / Am J Med 82:412~414
Klein AL / 1989 / Doppler characterization of leftventricular diastolic function in cardiac amyloidosis / J Am Coll Cardiol 13:1017~1026
Vogelsberg H / 2008 / Cardiovascular magneticresonance in clinically suspected cardiac amyloidosis: noninvasiveimaging compared to endomyocardial biopsy / J Am Coll Cardiol 51:1022~1030
Westermark P / 2002 / Amyloid fibril proteinnomenclature -- 2002 / Amyloid 9:197~200
Duston MA / 1987 / Diagnosis of amyloidosisby abdominal fat aspiration. Analysis of four years’ experience / Am J Med 82:412~414
Klein AL / 1989 / Doppler characterization of leftventricular diastolic function in cardiac amyloidosis / J Am Coll Cardiol 13:1017~1026
Vogelsberg H / 2008 / Cardiovascular magneticresonance in clinically suspected cardiac amyloidosis: noninvasiveimaging compared to endomyocardial biopsy / J Am Coll Cardiol 51:1022~1030
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