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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 630 - 636 (7page)
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Purpose: To determine whether statin use delays the development of castration-resistant prostate cancer (CRPC) in patients with metastatic prostate cancer treated with androgen deprivation therapy (ADT). Materials and Methods: A total of 171 patients with metastatic prostate cancer at the time of diagnosis who were treated with ADT between January 1997 and December 2013 were retrospectively analyzed. The patients were classified into two groups: the nonstatin use group (A group) and the statin use group (B group). Multivariate analysis was performed on statin use and other factors considered likely to have an effect on the time to progression to CRPC. Results: The mean patient age was 67.1±9.1 years, and the mean follow-up period was 52 months. The mean initial prostate-specific antigen (PSA) level was 537 ng/mL. Of the 171 patients, 125 (73%) were in group A and 46 (27%) were in group B. The time to progression to CRPC was 22.7 months in group A and 30.5 months in group B, and this difference was significant (p=0.032). Blood cholesterol and initial PSA levels did not differ significantly according to the time to progression to CRPC (p=0.288, p=0.198). Multivariate analysis using the Cox regression method showed that not having diabetes (p=0.037) and using a statin (p=0.045) significantly increased the odds ratio of a longer progression to CRPC. Conclusions: Statin use in metastatic prostate cancer patients appears to delay the progression to CRPC. Large-scale, long-term follow-up studies are needed to validate this finding.
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참고문헌 (28)
참고문헌 신청
Stewart BW / 2014 / World cancer report 2014
Hamilton RJ / 2008 / The influence of statin medications on prostate-specific antigen levels / J Natl Cancer Inst 100:1511~1518
Yang L / 2011 / Lovastatin causes diminished PSA secretion by inhibiting AR expression and function in LNCaP prostate cancer cells / Urology 77:1508.e1~1508.e7
Yokomizo A / 2011 / Statins reduce the androgen sensitivity and cell proliferation by decreasing the androgen receptor protein in prostate cancer cells / Prostate 71:298~304
Murtola TJ / 2007 / Cholesterollowering drugs and prostate cancer risk: a population-based case-control study / Cancer Epidemiol Biomarkers Prev 16:2226~2232
Hamilton RJ / 2008 / The influence of statin medications on prostate-specific antigen levels / J Natl Cancer Inst 100:1511~1518
Yang L / 2011 / Lovastatin causes diminished PSA secretion by inhibiting AR expression and function in LNCaP prostate cancer cells / Urology 77:1508.e1~1508.e7
Yokomizo A / 2011 / Statins reduce the androgen sensitivity and cell proliferation by decreasing the androgen receptor protein in prostate cancer cells / Prostate 71:298~304
Murtola TJ / 2007 / Cholesterollowering drugs and prostate cancer risk: a population-based case-control study / Cancer Epidemiol Biomarkers Prev 16:2226~2232
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