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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 310 - 317 (8page)
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Purpose: To investigate the potential benefits of testosterone administration to elderly men (>65 years) with late-onset hypogonadism (LOH) in comparison with younger men and to assess the safety of testosterone administration to elderly men.
Materials and Methods: A total of 561 hypogonadal men from two registry studies were divided into age groups of ≤65 years (group Y, n=450; range, 32–65 years) and >65 years (group O, n=111; range, 66–84 years). Following an initial 6-week interval, all men were treated with 3-month injections of parenteral testosterone undecanoate for up to 6 years.
Results: Over the 6 years, there was a progressive decrease of body weight and waist circumference. Beneficial effects on lipids and other metabolic factors and on psychological and sexual functioning progressed over the first 24 to 42 months and were sustained. Rather than a deterioration, there was an improvement of urinary parameters. Prostate volume and prostate-specific antigen increased moderately. Hematocrit levels increased but remained within safe margins.
Conclusions: The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins. Age itself need not be a contraindication to testosterone treatment of elderly men with LOH.
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참고문헌 (30)
참고문헌 신청
Huhtaniemi I / 2014 / Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment / Asian J Androl 16:192~202
Pye SR / 2014 / Late-onset hypogonadism and mortality in aging men / J Clin Endocrinol Metab 99:1357~1366
Zarotsky V / 2014 / Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men / Andrology 2:819~834
Corona G / 2010 / Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS) / J Sex Med 7:1362~1380
Wu FC / 2010 / Identification of late-onset hypogonadism in middle-aged and elderly men / N Engl J Med 363:123~135
Pye SR / 2014 / Late-onset hypogonadism and mortality in aging men / J Clin Endocrinol Metab 99:1357~1366
Zarotsky V / 2014 / Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men / Andrology 2:819~834
Corona G / 2010 / Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS) / J Sex Med 7:1362~1380
Wu FC / 2010 / Identification of late-onset hypogonadism in middle-aged and elderly men / N Engl J Med 363:123~135
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