지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.68 No.1
- 발행연도
- 2015.1
- 수록면
- 13 - 16 (4page)
이용수
초록· 키워드
오류제보하기
Background: Total oxygen consumption has been found to be reduced under deep neuromuscular blockade due to alower rate of metabolism of skeletal muscles. However, the magnitude of this effect in individual muscles has not been investigated.
Thus the aim of this study was to compare the oxygenation of paralyzed versus non-paralyzed forearm muscleunder tourniquet-provoked ischemia.
Methods: After ethics approval and written informed consent, 30 patients scheduled for elective hand and wrist surgerywere included. Ischemia was provoked by inflation of bilateral upper arm tourniquets and muscle relaxation was achievedvia intravenous administration of rocuronium 0.9 mg/kg. Bilateral tourniquets were applied to both upper arms beforeinduction of anesthesia and near infrared spectrometry (NIRS) electrodes applied on both forearms. Muscular ischemiain an isolated (= non-paralyzed, NP) as well as a paralyzed forearm (P) was created by sequential inflation of both tourniquetsbefore and after intravenous administration of rocuronium. Muscle oxygen saturations (SmO2) of NIRS in bothforearms and their changes were determined and compared.
Results: Data of 30 patients (15 male, 15 female; 41.8 ± 14.7 years) were analyzed. The speed of SmO2 decrease (50% decreaseof SmO2 from baseline (median [percentiles]: NP 210 s [180/480s] vs. P 180 [180/300]) as well as the maximumdecrease in SmO2 (minimum SmO2 in % (median [percentiles]: NP 20 [19/24] vs. P 21 [19/28]) were not significantly affectedby neuromuscular paralysis.
Conclusions: No significant effect of muscle relaxation on NIRS-assessed muscle oxygenation under tourniquet-inducedischemia was found in human forearm muscles.
목차
등록된 정보가 없습니다.
참고문헌 (7)
참고문헌 신청
Vernon DD / 2000 / Effect of neuromuscular blockade on oxygen consumption and energy expenditure in sedated, mechanically ventilated children / Crit Care Med 28:1569~1571
Steinhorn DM. / 1995 / Neuromuscular blockade provides no benefit over adequate sedation in ventilated dogs / J Crit Care 10:45~50
Marik PE / 1996 / The effects of neuromuscular paralysis on systemic and splanchnic oxygen utilization in mechanically ventilated patients / Chest 109:1038~1042
Freebairn RC / 1997 / Oxygen delivery, oxygen consumption, and gastric intramucosal pH are not improved by a computer-controlled, closed-loop, vecuronium infusion in severe sepsis and septic shock / Crit Care Med 25:72~77
Nishikawa H / 1993 / Pathology of warm ischaemia and reperfusion injury in adipomusculocutaneous flaps / Int J Exp Pathol 74:35~44
Steinhorn DM. / 1995 / Neuromuscular blockade provides no benefit over adequate sedation in ventilated dogs / J Crit Care 10:45~50
Marik PE / 1996 / The effects of neuromuscular paralysis on systemic and splanchnic oxygen utilization in mechanically ventilated patients / Chest 109:1038~1042
Freebairn RC / 1997 / Oxygen delivery, oxygen consumption, and gastric intramucosal pH are not improved by a computer-controlled, closed-loop, vecuronium infusion in severe sepsis and septic shock / Crit Care Med 25:72~77
Nishikawa H / 1993 / Pathology of warm ischaemia and reperfusion injury in adipomusculocutaneous flaps / Int J Exp Pathol 74:35~44
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