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자료유형
학술저널
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대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.38 No.1
발행연도
2014.1
수록면
13 - 24 (12page)

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The burgeoning epidemic of metabolic disease causes significant societal and individual morbidity and threatens the stability ofhealth care systems around the globe. Efforts to understand the factors that contribute to metabolic derangements are critical forreversing these troubling trends. While excess caloric consumption and physical inactivity superimposed on a susceptible geneticbackground are central drivers of this crisis, these factors alone fail to fully account for the magnitude and rapidity with whichmetabolic diseases have increased in prevalence worldwide. Recent epidemiological evidence implicates endocrine disruptingchemicals in the pathogenesis of metabolic diseases. These compounds represent a diverse array of chemicals to which humansare exposed via multiple routes in adulthood and during development. Furthermore, a growing ensemble of animal- and cellbasedstudies provides preclinical evidence supporting the hypothesis that environmental contaminants contribute to the developmentof metabolic diseases, including diabetes. Herein are reviewed studies linking specific endocrine disruptors to impairmentsin glucose homeostasis as well as tying these compounds to disturbances in insulin secretion and impairments in insulinsignal transduction. While the data remains somewhat incomplete, the current body of evidence supports the hypothesis thatour chemically polluted environment may play a contributing role in the current metabolic crisis.

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